Resting state functional connectivity differences between behavioral variant frontotemporal dementia and Alzheimer's disease.
Resting state functional connectivity differences between behavioral variant frontotemporal dementia and Alzheimer's disease.
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DOI：
10.3389/fnhum.2015.00474
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发表时间：
2015
影响因子：
2.9
通讯作者：
Rombouts SA
中科院分区：
文献类型：
--
作者：
Hafkemeijer A;Möller C;Dopper EG;Jiskoot LC;Schouten TM;van Swieten JC;van der Flier WM;Vrenken H;Pijnenburg YA;Barkhof F;Scheltens P;van der Grond J;Rombouts SA
阿尔茨海默病（AD）和行为变异额颞叶痴呆（bvFTD）是最常见的早发性痴呆类型。由于症状的异质性和重叠，早期区分两种类型的痴呆可能具有挑战性。本研究采用静息状态功能磁共振成像（fMRI）研究AD和bvFTD的脑功能连通性差异。方法：我们使用了来自两个痴呆症专业中心的31名AD患者、25名bvFTD患者和29名对照组的静息状态fMRI数据。我们研究了整个大脑的功能连接，应用了两种不同的分析技术，研究了网络到区域和区域到区域的连接。在控制生理噪声、年龄、性别、研究中心和区域灰质体积等因素的情况下，采用一般线性模型方法研究组间差异。结果：考虑到灰质的差异，我们观察到bvFTD中(a)外侧视觉皮质网络与外侧枕叶和楔叶皮层之间的网络到区域的连通性下降，以及(b)听觉系统网络和角回之间的连通性下降。在阿尔茨海默症中，我们发现背侧视觉流网络与外侧枕叶和顶叶眼皮层之间的网络-区域连通性下降。bvFTD患者颞上回与颞叶、牙碱上皮层、牙碱内皮层和舌回之间的区域间连通性降低。结论：AD与bvFTD的脑功能连通性病理生理存在差异。我们的研究结果支持静息状态fMRI显示疾病特异性功能连接差异的假设，并有助于阐明AD和bvFTD的病理生理。然而，功能连通性的组间差异并不像之前的研究显示的那么丰富。
Introduction: Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) are the most common types of early-onset dementia. Early differentiation between both types of dementia may be challenging due to heterogeneity and overlap of symptoms. Here, we apply resting state functional magnetic resonance imaging (fMRI) to study functional brain connectivity differences between AD and bvFTD. Methods: We used resting state fMRI data of 31 AD patients, 25 bvFTD patients, and 29 controls from two centers specialized in dementia. We studied functional connectivity throughout the entire brain, applying two different analysis techniques, studying network-to-region and region-to-region connectivity. A general linear model approach was used to study group differences, while controlling for physiological noise, age, gender, study center, and regional gray matter volume. Results: Given gray matter differences, we observed decreased network-to-region connectivity in bvFTD between (a) lateral visual cortical network and lateral occipital and cuneal cortex, and (b) auditory system network and angular gyrus. In AD, we found decreased network-to-region connectivity between the dorsal visual stream network and lateral occipital and parietal opercular cortex. Region-to-region connectivity was decreased in bvFTD between superior temporal gyrus and cuneal, supracalcarine, intracalcarine cortex, and lingual gyrus. Conclusion: We showed that the pathophysiology of functional brain connectivity is different between AD and bvFTD. Our findings support the hypothesis that resting state fMRI shows disease-specific functional connectivity differences and is useful to elucidate the pathophysiology of AD and bvFTD. However, the group differences in functional connectivity are less abundant than has been shown in previous studies.