RGS14 at the interface of hippocampal signaling and synaptic plasticity.
RGS14 at the interface of hippocampal signaling and synaptic plasticity.
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RGS14 位于海马信号传导和突触可塑性的界面。
DOI：
10.1016/j.tips.2011.07.005
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发表时间：
2011
影响因子：
13.8
通讯作者：
Hepler,JohnR
中科院分区：
文献类型：
--
作者：
Vellano,ChristopherP;Lee,SarahEmerson;Dudek,SerenaM;Hepler,JohnR
学习和记忆在大脑中被编码为突触的生化和物理变化，从而改变突触传递，这一过程称为突触可塑性。尽管人们对正向调节突触可塑性的因素了解很多，但对于负向调节这一过程的因素却知之甚少。最近，信号蛋白 RGS14（G 蛋白信号传导 14 的调节器）被确定为海马学习和记忆以及 CA2 海马神经元内突触可塑性的天然抑制因子。 RGS14 是一种多功能支架蛋白，整合了非常规 G 蛋白和丝裂原激活蛋白 (MAP) 激酶信号通路，这些信号通路本身就是突触可塑性、学习和记忆的关键调节因子。在这里，我们重点介绍了 RGS14 在大脑生理学和非常规 G 蛋白信号通路中的已知作用，并提出了分子模型来描述 RGS14 如何整合这些不同的信号通路来调节 CA2 海马神经元的突触可塑性。
Learning and memory are encoded within the brain as biochemical and physical changes at synapses that alter synaptic transmission, a process known as synaptic plasticity. Although much is known about factors that positively regulate synaptic plasticity, very little is known about factors that negatively regulate this process. Recently, the signaling protein RGS14 (Regulator of G protein Signaling 14) was identified as a natural suppressor of hippocampal-based learning and memory as well as synaptic plasticity within CA2 hippocampal neurons. RGS14 is a multifunctional scaffolding protein that integrates unconventional G protein and mitogen-activated protein (MAP) kinase signaling pathways that are themselves key regulators of synaptic plasticity, learning, and memory. Here, we highlight the known roles for RGS14 in brain physiology and unconventional G protein signaling pathways, and propose molecular models to describe how RGS14 may integrate these diverse signaling pathways to modulate synaptic plasticity in CA2 hippocampal neurons.