Immature frontal lobe contributions to cognitive control in children: Evidence from fMRI
Immature frontal lobe contributions to cognitive control in children: Evidence from fMRI
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DOI：
10.1016/s0896-6273(01)00583-9
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发表时间：
2002-01-17
期刊：
影响因子：
16.2
通讯作者：
Gabrieli, JDE
中科院分区：
文献类型：
--
作者：
Bunge, SA;Dudukovic, NM;Gabrieli, JDE
事件相关功能磁共振成像的特点之间的差异，8-12岁的儿童和成人有关的两种形式的认知控制：干扰抑制和反应抑制的大脑激活。与成人相比，儿童更容易受到干扰，抑制不适当反应的能力更差。儿童有效的干扰抑制与相对于成人的对侧半球的前额叶激活有关。与此相反，儿童的有效反应抑制与成人激活的后额叶区域有关，而与成人激活的前额叶区域无关。儿童无法激活右腹外侧前额叶皮层中的一个区域，而成年人则负责这两种类型的认知控制。因此，儿童表现出不成熟的前额叶激活，根据所需的认知控制类型而变化。
Event-related fMRI was employed to characterize differences in brain activation between children ages 8-12 and adults related to two forms of cognitive control: interference suppression and response inhibition. Children were more susceptible to interference and less able to inhibit inappropriate responses than were adults. Effective interference suppression in children was associated with prefrontal activation in the opposite hemisphere relative to adults. In contrast, effective response inhibition in children was associated with activation of posterior, but not prefrontal, regions activated by adults. Children failed to activate a region in right ventrolateral prefrontal cortex that was recruited for both types of cognitive control by adults. Thus, children exhibited immature prefrontal activation that varied according to the type of cognitive control required.