GROWTH CURVE OF AN EXPERIMENTAL SOLID TUMOR FOLLOWING RADIOTHERAPY
GROWTH CURVE OF AN EXPERIMENTAL SOLID TUMOR FOLLOWING RADIOTHERAPY
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DOI：
10.1093/jnci/58.6.1735
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发表时间：
1977-01-01
影响因子：
10.3
通讯作者：
SIMON, R
中科院分区：
文献类型：
--
作者：
NORTON, L;SIMON, R
大多数未经治疗的肿瘤的生长可以用Gompertzian或指数增长曲线很好地描述，但治疗后肿瘤的生长从来没有很好的数学特征。一个不依赖于限制性假设或不可测量变量的方程被开发出来，它能够描述受扰动和未受扰动的增长。对于3964A大鼠肝癌，导出了放疗剂量水平与生长曲线反应之间的函数关系，并用于预测目的。研究了肿瘤大小与治疗敏感性之间的隐含关系以及一些临床意义。
The growth of most untreated tumors is well described by Gompertzian or exponential growth curves, but the growth of treated tumors was never well characterized mathematically. An equation was developed that, while not dependent on restrictive assumptions or unmeasurable variables, was capable of describing perturbed as well as unperturbed growth. For the 3964A rat hepatoma, a functional relationship between dose level of radiotherapy and growth curve response was derived and used for predictive purposes. An implied relationship between tumor size and sensitivity to therapy and some clinical implications were examined.