Sticking the Landing: Enhancing Liposomal Cell Delivery using Reversible Covalent Chemistry and Caged Targeting Groups
Sticking the Landing: Enhancing Liposomal Cell Delivery using Reversible Covalent Chemistry and Caged Targeting Groups
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坚持着陆：利用可逆共价化学和笼状靶向基团增强脂质体细胞递送
DOI：
10.1002/cbic.202200436
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发表时间：
2022
期刊：
影响因子：
3.2
通讯作者：
Best, Michael D.
中科院分区：
文献类型：
--
作者：
Lou, Jinchao;Qualls, Megan L.;Best, Michael D.
脂质体是用于包封和递送广泛的治疗性货物的高效纳米载体。虽然脂质体设计的进步已经改善了几个药理学特性，但将受益于进一步进展的一个重要领域涉及细胞靶向和进入。在这篇概念文章中，我们将重点介绍利用可逆共价键和笼化基团等策略激活脂质体细胞进入的最新进展。这些方法利用了在包括分子传感和化学生物学在内的互补领域中取得的进步，并将该技术导向控制脂质体细胞递送特性。用包括硼酸和环状二硫化物的基团装饰脂质体被呈现为通过与细胞表面上的官能团反应来驱动递送的手段。此外，可以利用笼化基团仅在遇到靶刺激时激活细胞递送。这些方法为在下一代脂质体治疗性纳米载体的开发中控制细胞递送提供了有前途的新途径。
Liposomes are highly effective nanocarriers for encapsulating and delivering a wide range of therapeutic cargo. While advancements in liposome design have improved several pharmacological characteristics, an important area that would benefit from further progress involves cellular targeting and entry. In this concept article, we will focus on recent progress utilizing strategies including reversible covalent bonding and caging groups to activate liposomal cell entry. These approaches take advantage of advancements that have been made in complementary fields including molecular sensing and chemical biology and direct this technology toward controlling liposome cell delivery properties. The decoration of liposomes with groups including boronic acids and cyclic disulfides is presented as a means for driving delivery through reaction with functional groups on cell surfaces. Additionally, caging groups can be exploited to activate cell delivery only upon encountering a target stimulus. These approaches provide promising new avenues for controlling cell delivery in the development of next‐generation liposomal therapeutic nanocarriers.