Mainstream smoke constituents and in vitro toxicity comparative analysis of 3R4F and 1R6F reference cigarettes
Mainstream smoke constituents and in vitro toxicity comparative analysis of 3R4F and 1R6F reference cigarettes
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DOI：
10.1016/j.toxrep.2019.02.009
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发表时间：
2019-01-01
影响因子：
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通讯作者：
Esposito, Marco
中科院分区：
文献类型：
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作者：
Jaccard, Guy;Djoko, Donatien Tafin;Esposito, Marco
一种新的肯塔基州参考卷烟1R6F已经制造出来，以取代正在耗尽的3R4F参考卷烟。3R4F肯塔基参比卷烟已被广泛用作主流烟雾分析和卷烟及新型烟草制品的体内外毒理学数据的监测或比对卷烟。这两种参考香烟在同一时间段内在同一实验室进行了分析，目的是进行3R4F和1R6F的比较。根据气溶胶化学和体外测定的结果，我们认为1R6F参比卷烟是一种合适的替代3R4F参比卷烟作为比较器/监测器的卷烟。在以烟草加热系统2.2为例进行对比试验的基础上，对其作为新型烟草产品比较器的具体用途进行了检验。
A new Kentucky reference cigarette, 1R6F, has been manufactured to replace the depleting 3R4F reference cigarette. The 3R4F Kentucky reference cigarettes have been widely used as monitor or comparator cigarettes for mainstream smoke analysis and in vitro and in vivo toxicological data of cigarettes and novel tobacco products. Both reference cigarettes were analyzed in the same laboratory during the same period of time with the goal of performing a comparison of 3R4F and 1R6F. On the basis of the results obtained from aerosol chemistry and in vitro assays, we consider that the 1R6F reference cigarette is a suitable replacement for the 3R4F reference cigarette as a comparator/monitor cigarette. Its specific use as a comparator for novel tobacco products was checked on the basis of a comparative test with the Tobacco Heating System 2.2 as an example.