The Effects of Antihypertensive Agents on Atherosclerosis-Related Parameters of Human Aorta Intimal Cells
The Effects of Antihypertensive Agents on Atherosclerosis-Related Parameters of Human Aorta Intimal Cells
复制标题
降压药对人主动脉内膜细胞动脉粥样硬化相关参数的影响
DOI：
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
E. M. Pivovarova
中科院分区：
文献类型：
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作者：
A. Orekhov;V. Tertov;E. M. Pivovarova
四种降压药-氨氯地平、维拉帕米、心得安和培哚普利拉-在人细胞培养中进行了研究。用未受累的人主动脉内膜细胞和冠状动脉粥样硬化患者的致动脉粥样硬化血清研究抗动脉粥样硬化的活性。氨氯地平和维拉帕米显著抑制血清诱导的培养细胞胆固醇含量、细胞增殖活性和蛋白质合成的增加。心得安增加了所有三个参数，而培哚普利拉则没有影响。此外，氨氯地平和维拉帕米显著降低动脉粥样硬化斑块来源的平滑肌细胞内胆固醇含量，抑制细胞增殖和蛋白质合成。心得安增加了所有这些参数，而培哚普利拉没有影响。维拉帕米和氨氯地平的抗动脉粥样硬化和致动脉粥样硬化作用在体外模型中得到证实。这些研究表明氨氯地平比维拉帕米有更好的抗动脉粥样硬化作用。培哚普利拉对动脉粥样硬化参数有中性影响，而心得安的作用似乎是潜在的有害作用。
Four antihypertensive agents – amlodipine, verapamil, propranolol and perindoprilat – were studied in human cell cultures. Antiatherogenic activity was investigated using uninvolved human aortic smooth muscle intima cells and atherogenic serum obtained from patients with coronary atherosclerosis. Amlodipine and verapamil significantly inhibited serum-induced increases in cholesterol content, cell-proliferative activity and protein synthesis in the cultured cells. Propranolol increased all three parameters, while perindoprilat had no effects. In addition, amlodipine and verapamil significantly lowered the intracellular cholesterol content of smooth muscle cells derived from atherosclerotic plaque and inhibited cell proliferation and protein synthesis. Propranolol increased all of these parameters, while perindoprilat produced no effects. The antiatherogenic and antiatherosclerotic actions of verapamil and amlodipine were confirmed in an ex vivo model. These studies demonstrated a beneficial antiatherosclerotic effect of amlodipine that was greater than that of verapamil. Perindoprilat had a neutral effect on atherosclerotic parameters, while the action of propranolol appeared to be potentially detrimental.
β-肾上腺素能阻断剂对动脉粥样硬化及其并发症的影响。
影响因子：
39.3
作者：
Kaplan,JR;Manuck,SB;Adams,MR;Clarkson,TB
通讯作者：
Clarkson,TB