Biochemical sensor tubing for point-of-care monitoring of intravenous drugs and metabolites
Biochemical sensor tubing for point-of-care monitoring of intravenous drugs and metabolites
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DOI：
10.1039/c2lc20586f
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发表时间：
2012-01-01
期刊：
影响因子：
6.1
通讯作者：
Cunningham, Brian T.
中科院分区：
文献类型：
--
作者：
Choi, Charles J.;Wu, Hsin-Yu;Cunningham, Brian T.
在医疗设施中，存在开发检测系统的强烈动机，该检测系统可以提供对用于从患者身体输送或移除流体的医疗管道中的流体的连续分析。可能的应用包括提高静脉（IV）药物注射和护理点健康监测安全性的系统。在这项工作中，我们将一个表面增强的拉曼散射（Sers）传感器组成的阵列紧密间隔的金属纳米圆顶到柔性管通常用于静脉药物输送和导尿管。纳米圆顶传感器是通过低成本、大面积的工艺制造的，该工艺能够实现单次使用的一次性操作。作为示例性证明，传感器用于动态检测在其临床相关浓度范围内的异丙嗪（止痛药）和尿素（尿代谢物）。使用每种分析物的不同Sers峰来证明分析物的单独检测和共检测。
In medical facilities, there is strong motivation to develop detection systems that can provide continuous analysis of fluids in medical tubing used to either deliver or remove fluids from a patient's body. Possible applications include systems that increase the safety of intravenous (IV) drug injection and point-of-care health monitoring. In this work, we incorporated a surface-enhanced Raman scattering (SERS) sensor comprised of an array of closely spaced metal nanodomes into flexible tubing commonly used for IV drug delivery and urinary catheters. The nanodome sensor was fabricated by a low-cost, large-area process that enables single use disposable operation. As exemplary demonstrations, the sensor was used to kinetically detect promethazine (pain medication) and urea (urinary metabolite) within their clinically relevant concentration ranges. Distinct SERS peaks for each analyte were used to demonstrate separate detection and co-detection of the analytes.