Effect of cobalt(II) complexes with dipyridylamine and salicylaldehydes on cultured tumor and non-tumor cells: Synthesis, crystal structure investigations and biological activity
Effect of cobalt(II) complexes with dipyridylamine and salicylaldehydes on cultured tumor and non-tumor cells: Synthesis, crystal structure investigations and biological activity
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DOI：
10.1016/j.jinorgbio.2012.08.022
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发表时间：
2012-12-01
影响因子：
3.9
通讯作者：
Tsitouroudi, Fani
中科院分区：
文献类型：
--
作者：
Lalia-Kantouri, Maria;Gdaniec, Maria;Tsitouroudi, Fani
合成了8个含2，2‘-联吡啶胺(DpamH)和取代水杨醛(X-Saloh)的混配钴(II)配合物，以期发现具有抗癌活性的新化合物。通式为[Co(DpamH)(2)(X-salo)]Y，(Y=溴或氯)的配合物经元素分析、红外光谱、紫外可见光谱、磁学和电导测试进行了表征。其中两个化合物[Co(DpamH)(2)(5-CH3-salo)]Br和[Co(DpamH)(2)(3-OCH3-salo)]Cl以及前驱体[Co(DpamH)(3)]Br2和[Co(DpamH)(2)Cl(H2O)]Cl的结构经X-射线单晶测定，揭示了钴(II)与单核配合物的八面体配位。用TG/DTG-DTA联用技术研究了配合物在氮气气氛中的热稳定性，最高可达200℃。两个前体钴化合物以及四个标题化合物作为抗癌剂对不同的癌症和正常人类细胞株进行了评估。采用SRB比色法测定细胞生长抑制率，评价不同细胞系对钴配合物的体外化疗敏感性。一系列实验表明，这些络合物对所有使用的细胞系具有剂量依赖的细胞毒活性。这些发现提示人们去寻找这些复合体与其他对细胞增殖至关重要的细胞成分之间可能存在的相互作用。(C)2012 Elsevier Inc.保留所有权利。
The synthesis of eight mixed-ligand cobalt(II) complexes with 2,2'-dipyridylamine (dpamH) and substituted salicylaldehydes (X-saloH) was undertaken in an effort to discover new compounds with anticancer activity. The complexes with the general formula [Co(dpamH)(2)(X-salo)]Y, (Y=Br or Cl) were characterized by elemental analyses, FT-IR and UV-visible spectroscopy, magnetic and conductivity measurements. The structures of two of them [Co(dpamH)(2)(5-CH3-salo)]Br and [Co(dpamH)(2)(3-OCH3-salo)]Cl, as well as of the precursors [Co(dpamH)(3)]Br-2 and [Co(dpamH)(2)Cl(H2O)]Cl, were determined by X-ray crystallography revealing octahedral coordination of cobalt(II) and mononuclear complexes. The complexes were thermally stable up to 200 degrees C in nitrogen atmosphere, studied by simultaneous TG/DTG-DTA technique. The two precursor Co compounds, as well as four of the title compounds, were evaluated for their efficacy as anticancer agents against different cancer and normal human cell lines. The in vitro chemosensitivity of various human cell lines to these Co complexes was evaluated by measuring cell growth inhibition by employing the SRB colorimetric assay. A series of experiments showed a dose-dependent cytotoxic activity of the complexes against all cell lines used. These findings represent a prompting to search for possible interaction of these complexes with other cellular elements of fundamental importance in cell proliferation. (C) 2012 Elsevier Inc. All rights reserved.