Agreement between GPRD smoking data: a survey of general practitioners and a Population-based survey
Agreement between GPRD smoking data: a survey of general practitioners and a Population-based survey
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DOI：
10.1002/pds.902
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发表时间：
2004-07-01
影响因子：
2.6
通讯作者：
Brensinger, C
中科院分区：
文献类型：
--
作者：
Lewis, JD;Brensinger, C
背景 吸烟是一种常见的习惯，与许多疾病有关。吸烟通常是药物流行病学研究中一个重要的混杂变量。一般实践研究数据库（GPRD）广泛应用于药物流行病学研究。在本研究中，我们将 GPRD 中记录的数据与通过直接询问全科医生 (GP) 和基于人群的调查获得的吸烟史进行比较。 方法 我们完成了一项对 150 名炎症性肠病患者的随机样本护理的全科医生的邮寄调查。该调查要求全科医生在指定日期对患者的吸烟状况进行分类。然后将这些结果与 GPRD 中记录的数据进行比较。将随机选择的 225 308 名不患有炎症性肠病的 GPRD 患者的吸烟状况与基于人群的家庭调查结果进行比较。结果 150 名患者中，有 136 名患者 (91%) 收到了全科医生提供的完整调查和可用数据。该数据库对当前吸烟情况的敏感性和阳性预测值分别为 78% (95% CI: 52-94) 和 70% (95% CI: 46-88)。既往吸烟的敏感性和阳性预测值分别为 53% (95% CI: 28-77) 和 60% (95% CI: 32-84)。根据基于人口的调查，GPRD 当前和以前吸烟率分别为预期吸烟率的 79% 和 29%。 结论 GPRD 中当前吸烟记录比以前吸烟记录更完整。在规划 GPRD 研究时需要考虑这些数据，其中吸烟是一个重要的暴露变量。版权所有 (C) 2003 John Wiley Sons, Ltd.
Background Cigarette smoking is a common habit that is associated with many diseases. Smoking is often an important confounding variable in pharmacoepidemiological studies. The General Practice Research Database (GPRD) is widely used in pharmacoepidemiological research. In this study, we compare data recorded in the GPRD with the smoking history obtained from direct query of general practitioners (GPs) and from a population-based survey.Methods We completed a mailed survey of GPs caring for a random sample of 150 patients with inflammatory bowel disease. The survey asked the GP to categorize the patients smoking status on a specified date. These results were then compared to the data recorded in the GPRD. Smoking status of 225 308 randomly selected GPRD patients without inflammatory bowel disease was compared to the results of a population-based household survey.Results Completed surveys with usable data were received from GPs on 136 of the 150 patients (91%). The sensitivity and positive predictive value of the database for current smoking were 78% (95% CI: 52-94) and 70% (95% CI: 46-88) respectively. The sensitivity and positive predictive value of former smoking were 53% (95% CI: 28-77) and 60% (95% CI: 32-84) respectively. Current and former smoking rates in the GPRD were 79% and 29% respectively of expected rates according to the population-based survey.Conclusions Current smoking is more completely recorded in the GPRD than former smoking. These data need to be considered when planning GPRD studies where smoking is an important exposure variable. Copyright (C) 2003 John Wiley Sons, Ltd.