Exercise training decreases expression of inflammation-related adipokines through reduction of oxidative stress in rat white adipose tissue
Exercise training decreases expression of inflammation-related adipokines through reduction of oxidative stress in rat white adipose tissue
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DOI：
10.1016/j.bbrc.2008.12.127
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发表时间：
2009-02-06
影响因子：
3.1
通讯作者：
Ohno, Hideki
中科院分区：
文献类型：
--
作者：
Sakurai, Takuya;Izawa, Tetsuya;Ohno, Hideki
脂肪细胞氧化应激增加导致炎症相关脂肪因子表达失调。我们研究了运动训练对大鼠白色脂肪组织（WAT）氧化应激的影响，特别是关注炎症相关的脂肪因子。运动训练组大鼠WAT中脂质过氧化水平低于对照组。TR大鼠WAT中含锰超氧化物歧化酶含量较C大鼠增加。与此相反，NADPH氧化酶NOX 2蛋白在WAT的表达下调运动训练。此外，TR大鼠WAT中炎症相关脂肪因子如肿瘤坏死因子-α和单核细胞趋化蛋白-1的水平低于C大鼠。运动训练对内脏WAT的影响比皮下WAT更显著。这些结果表明，运动训练通过减少WAT中的氧化应激来减少炎症相关脂肪因子的表达。(C)2008年爱思唯尔公司All rights reserved.
Increased oxidative stress in adipocytes causes dysregulated expression of inflammation-related adipokines. We have examined the effects of exercise training on oxidative stress in rat white adipose tissue (WAT), especially focusing on inflammation-related adipokines. The levels of lipid peroxidation in WAT of exercise-trained (TR) rats were lower than those ill Control (C) rats. The content of manganese-containing Superoxide dismutase in WAT of TR rats was increased as compared with those in C rats. In contrast, the expression of the NADPH oxidase NOX2 protein in WAT was downregulated by exercise training. Moreover, the levels of inflammation-related adipokines, Such as tumor necrosis factor-alpha and monocyte chemoattractant protein-1, in WAT of TR rats were lower than those in C rats. The effects of exercise training were more remarkable in visceral WAT than in subcutaneous. These results Suggest that exercise training decreases the expression of inflammation-related adipokines by reducing oxidative stress in WAT. (C) 2008 Elsevier Inc. All rights reserved.