Imaging modalities for monitoring acute therapeutic effects after near-infrared photoimmunotherapy in vivo
Imaging modalities for monitoring acute therapeutic effects after near-infrared photoimmunotherapy in vivo
复制标题
用于监测体内近红外光免疫治疗后急性治疗效果的成像方式
DOI：
10.1002/jbio.202100266
复制
发表时间：
2022
影响因子：
2.8
通讯作者：
Takuo Ogihara
中科院分区：
文献类型：
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作者：
Xieyi Zhang;Takahito Nakajima;Kenta Mizoi;Yoshito Tsushima;Takuo Ogihara
近红外光免疫疗法（NIR‐PIT）在用近红外（NIR）光照射后诱导立即细胞死亡。在肿瘤大小改变之前，NIR‐PIT引起的急性治疗效果必须通过成像模式进行监测。我们总结并比较了近红外-PIT术后急性疗效评价的成像方式，旨在更好地了解每种方式的优缺点，以供临床应用评价。具有高分辨率的荧光成像和荧光寿命保持正常器官中荧光染料的高积累。高分辨率和无创性是磁共振成像的主要优势，而18F-氟脱氧葡萄糖正电子发射断层扫描提供有关葡萄糖代谢的信息。光学相干断层扫描提供了有关血管的更多信息。因此，所有的成像方式在评估NIR‐PIT后的急性治疗效果中发挥着重要作用。临床应用时应根据具体目的和条件选择合适的模态。
Near‐infrared photoimmunotherapy (NIR‐PIT) induces immediate cell death after irradiation with near‐infrared (NIR) light. Acute therapeutic effects caused by NIR‐PIT before the change of tumor size is essential to be monitored by imaging modalities. We summarized and compared the imaging modalities for evaluating acute therapeutic effects after NIR‐PIT, and aimed to provide a better understanding of advantages and disadvantages of each modality for evaluation in clinical applications. Fluorescence imaging and fluorescence lifetime, with high resolution, remains high accumulation of fluorescence dyes in the normal organs. High resolution and noninvasiveness are the major advantages of magnetic resonance imaging, while18F‐fluorodeoxyglucose positron emission tomography provides information about the glucose metabolism. Optical coherence tomography provided more information about the blood vessels. Thus, all of the imaging modalities play an important role in evaluating acute therapeutic effects after NIR‐PIT. Clinicians should choose suitable modality according to specific purpose and conditions in clinical application.