Inertia of amoebic cell locomotion as an emergent collective property of the cellular dynamics
Inertia of amoebic cell locomotion as an emergent collective property of the cellular dynamics
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DOI：
10.1103/physreve.71.010902
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发表时间：
2005-01-01
影响因子：
2.4
通讯作者：
Sasai, M
中科院分区：
文献类型：
--
作者：
Nishimura, SI;Sasai, M
阿米巴细胞在许多物种中普遍存在，已被用作研究真核细胞运动的模型系统。我们构建了一个二维网格上的阿米巴细胞模型，以统一的方式描述感知、细胞状态和运动。结果表明，模拟细胞的平均位置可用二阶运动方程来描述，初始时刻的机械推动促进了细胞的运动，当细胞从推力中解脱出来后，这种运动将继续下去。这些类似惯性的特征表明，在信号分子的化学分布中，可能存在牛顿运动。作为一个例子，我们展示了“向心”分布中旋转运动的可能性。观察到的惯性运动是一个紧急的集体动力学，它受细胞内的扩散和化学过程控制。
Amoebic cells are ubiquitous in many species and have been used as model systems to study the eukaryotic cellular locomotion. We construct a model of amoebic cells on two-dimensional grids, which describes sensing, cell status, and locomotion in a unified way. We show that the averaged position of simulated cells is described by a second-order differential equation of motion and that the mechanical pushing at the initial moment boosts the cell movement, which continues after the cell is released from the pushing. These "inertialike" features suggest the possibility of Newtonian-type motions in chemical distributions of the signaling molecule. We show, as an example, the possibility of rotating motion in a "centripetal" distribution. The observed inertial motion is an emergent collective dynamics, which is controlled by diffusive and chemical processes in the cell.