Bacterial adherence and the glycocalyx and their role in musculoskeletal infection
Bacterial adherence and the glycocalyx and their role in musculoskeletal infection
复制标题
细菌粘附和糖萼及其在肌肉骨骼感染中的作用
DOI：
10.1055/s-0030-1267133
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
J. Costerton
中科院分区：
文献类型：
--
作者：
A. Gristina;J. Costerton
细菌产生一种毒力相关的多糖胞外黏液（糖萼），它优先粘附在生物材料和受损组织的表面。这种生物膜可以抵抗抗生素的渗透，并提供一定程度的抗体和巨噬细胞的保护。在自然环境和细菌-动物细胞疾病状态中也发现了类似的细胞-基质粘附现象。在存在生物材料和受损组织的情况下，附着的糖杯是增加感染易感性的根本原因之一，也是这种感染持续存在直到移除假体装置的重要因素。
Bacteria produce a virulence-related polysaccharide exocellular slime (the glycocalyx), which preferentially adheres to the surfaces of biomaterials and compromised tissues. This biofilm resists antibiotic penetration and provides a degree of protection from antibodies and macrophages. Similar adhesive cell-to-substrate phenomena have been noted in natural environments and in bacterial-animal cell disease states. The adherent glycocalyx is one of the fundamental reasons for increased susceptibility to infection in the presence of biomaterials and compromised tissues and a significant factor in the persistence of such infection until the removal of the prosthetic device.