Oxidative DNA base damage by the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine)
Oxidative DNA base damage by the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine)
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DOI：
10.1016/s0960-894x(02)00468-7
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发表时间：
2002-09-02
影响因子：
2.7
通讯作者：
Gates, KS
中科院分区：
文献类型：
--
作者：
Kotandeniya, D;Ganley, B;Gates, KS
替拉扎明是一种生物还原激活的 DNA 损伤剂，可选择性杀死实体瘤中的缺氧细胞。在这项工作中，碱基切除修复酶被用来提供证据，证明替拉扎明对双链 DNA 中的嘌呤和嘧啶残基造成大量损伤。 (C) 2002 Elsevier Science Ltd. 保留所有权利。
Tirapazamine is a bioreductively activated DNA-damaging agent that selectively kills the hypoxic cells found in solid tumors. In this work, base excision repair enzymes were used to provide evidence that tirapazamine causes significant amounts of damage to both purine and pyrimidine residues in double-stranded DNA. (C) 2002 Elsevier Science Ltd. All rights reserved.