Time-dependent behavioral, neurochemical, and immune consequences of repeated experiences of social defeat stress in male mice and the ameliorative effects of fluoxetine
Time-dependent behavioral, neurochemical, and immune consequences of repeated experiences of social defeat stress in male mice and the ameliorative effects of fluoxetine
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DOI：
10.1016/j.bbi.2004.11.002
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发表时间：
2005-11-01
影响因子：
15.1
通讯作者：
Arregi, A
中科院分区：
文献类型：
--
作者：
Beitia, G;Garmendia, L;Arregi, A
这项研究试图确定反复失败的不同天数是否会改变小鼠的行为、免疫指标和神经内分泌介质。在感官接触模型中，1只雄性小鼠因反复失败而受到社会压力。与经历23次失败的受试者相比，经历9次失败的受试者表现出更多的伸展注意姿势，而更少的积极防御因素。有九次失败经历的顺从受试者的脾细胞增殖反应也低于未接受治疗的对照组。与社会压力受试者相比，操控对照组的增殖指数逐渐增加，但速度更快，导致在暴露于社会应激源23天后产生显著的免疫抑制效应。9天的暴露导致下丘脑的5-羟色胺和多巴胺与它们的主要代谢物的比率高于未经操纵或操纵的对照组和23天的社交压力受试者。这些数据通常表明，严重的社会压力(如九次失败)会产生一系列行为和生理变量，这些变量是焦虑状态的特征。在52天的社会压力后，细胞增殖指数也低于操控对照组。氟西汀治疗似乎有缓解焦虑的效果，减少不动，甚至似乎保护受试者免受社会应激源引起的免疫损伤和内分泌改变。这些结果通常会提供一些线索，帮助我们更好地了解社会压力的后果及其可能的治疗方法。(C)2004 Elsevier Inc.保留所有权利。
This study attempted to determine whether differing numbers of days of repeated defeat experience altered behavior, immune measures, and neuroendocrine mediators in mice. OF 1 male mice were socially stressed by repeated experiences of defeat in a sensorial contact model. Subjects exposed to nine defeats showed more stretch-attend postures and fewer active defense elements than counterparts exposed to 23 defeats. Submissive subjects with nine experiences of defeat also had a lower splenocyte proliferative response than unmanipulated controls. The proliferation index progressively increased but at a higher rate in manipulated controls than in socially stressed subjects, resulting in a significant immunosuppressive effect after 23 days of exposure to social stressors. Nine days of such exposure resulted in higher hypothalamic ratios of serotonin and dopamine to their major metabolites than in unmanipulated or manipulated controls and subjects socially stressed for 23 days. The data generally indicate that the acute social stressors (such as nine defeats) produce a profile of behavioral and physiological variables characteristic of a state of anxiety. The proliferation index was also lower after 52 days of social stress than in manipulated controls. Fluoxetine treatment appeared to have an anxiolytic effect, reducing immobility, and even seemed to protect subjects from the immune impairment and endocrine alteration caused by social stressors. The results generally provide clues that improve our knowledge of the consequences of social stressors and their possible treatment. (c) 2004 Elsevier Inc. All rights reserved.