ASSESSMENT OF RISK FOR PERIODONTAL-DISEASE .2. RISK INDICATORS FOR ALVEOLAR BONE LOSS
ASSESSMENT OF RISK FOR PERIODONTAL-DISEASE .2. RISK INDICATORS FOR ALVEOLAR BONE LOSS
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DOI：
10.1902/jop.1995.66.1.23
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发表时间：
1995-01-01
影响因子：
4.3
通讯作者：
HAUSMANN, E
中科院分区：
文献类型：
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作者：
GROSSI, SG;GENCO, RJ;HAUSMANN, E
这项研究调查了牙周感染相关的牙槽骨丢失的风险指标。对来自纽约州伊利县的1361名年龄在25岁到74岁之间的受试者进行了近端牙槽间骨丢失和潜在的解释变量的评估，这些变量包括年龄、性别、全身疾病史、吸烟和8种龈下细菌的存在。测量从牙槽骨至CEJ的近侧牙槽骨间骨丢失，并计算每个受试者的平均值。每个受试者的平均骨丢失(BL)范围为0.4-8.8 mm，该结果变量被分成4个有序类别。使用有序逐步Logistic回归模型检验解释变量与BL之间的关联度。与更严重的骨丢失呈正相关的因素包括：牙龈下定植福赛瑟菌(O.R.，2.52；95%CI：1.98至3.17)或牙龈假单胞菌(O.R.1.73；95%CI：1.27至2.37)，种族(土著美洲人、亚洲人或太平洋岛民)，O.R.2.40(95%CI：1.21至4.79)，以及性别，男性的患病几率高于女性。与非吸烟者相比，吸烟者发生更严重骨质流失的几率更高，范围分别为3.25(95%可信区间：2.33至4.54)至7.28(95%可信区间：5.09至10.31)。年龄较大的人也表现出更严重的骨丢失水平。肾脏病史(手术率0.55；95%可信区间：0.35~0.89)和过敏史(手术史0.76；95%可信区间：0.59~0.98)与骨质丢失的严重程度呈负相关。牙槽骨丢失的严重程度与年龄、吸烟、种族和牙周炎或牙周炎杆菌的定植有关。这项研究和其他旨在确定与牙周病相关的真实危险因素的研究可能会导致旨在减少可改变的危险因素的有害影响的预防措施。
THIS STUDY EXAMINED THE RISK INDICATORS for alveolar bone loss associated with periodontal infection. A cross-section of 1,361 subjects aged 25 to 74 years, from Erie County, NY were evaluated for interproximal alveolar bone loss and potential explanatory variables including age, gender, history of systemic diseases, smoking, and presence of 8 subgingival bacteria. Interproximal alveolar bone loss was measured from the alveolar crest to the CEJ and a mean computed for each subject. The mean bone loss per subject (BL) ranged from 0.4 to 8.8 mm, and this outcome variable was grouped into 4 ordered categories. The degree of association between the explanatory variables and BL was examined utilizing an ordinal stepwise logistic regression model. Factors which were positively associated with more severe bone loss included subgingival colonization with B. forsythus (O.R, 2.52; 95% CI: 1.98 to 3.17) or P. gingivalis (O.R. 1.73; 95% CI: 1.27 to 2.37), race (Native American, Asian, or Pacific Islanders) with an O.R. 2.40 (95% CI: 1.21 to 4.79), and gender with males having higher odds than females. Smokers had greater odds for more severe bone loss compared to non-smokers ranging from 3.25 (95% CI: 2.33 to 4.54) to 7.28 (95% CI: 5.09 to 10.31) for light and heavy smokers, respectively. Individuals at older ages also showed more severe levels of bone loss. History of kidney disease (O.R. 0.55; 95% CI: 0.35 to 0.89) and history of allergies (O.R. 0.76; 95% CI: 0.59 to 0.98) were inversely associated with severity of bone loss. Severity of alveolar bone loss is associated with increasing age, smoking, race, and colonization with subgingival B. forsythus or P. gingivalis. This and other studies directed to identifying true risk factors associated with periodontal disease may lead to preventive measures directed to reducing the deleterious effects of modifiable risk factors.