Decreased B Cells on Admission Associated With Prolonged Viral RNA Shedding From the Respiratory Tract in Coronavirus Disease 2019: A Case-Control Study
Decreased B Cells on Admission Associated With Prolonged Viral RNA Shedding From the Respiratory Tract in Coronavirus Disease 2019: A Case-Control Study
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入院时 B 细胞减少与 2019 年冠状病毒病呼吸道病毒 RNA 长时间脱落相关：一项病例对照研究
DOI：
10.1093/infdis/jiaa311
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发表时间：
2020-08-01
影响因子：
6.4
通讯作者：
Sheng, Jifang
中科院分区：
文献类型：
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作者：
Hao, Shaorui;Lian, Jiangshan;Sheng, Jifang
摘要严重急性呼吸综合征冠状病毒2型的病毒RNA脱落时间（VST）尚未得到很好的表征。收集临床数据，并比较短VST和长VST患者（分别位于下四分位数和上四分位数）。逆转录聚合酶链反应结果连续3次阴性后，复发阳性的概率急剧下降至4.8%。一系列≥3个连续阴性结果适合作为病毒RNA脱落结束的标准。入院时B细胞计数正常的患者的呼吸道脱落VST显著短于B细胞计数降低的患者（中位数[四分位距]，分别为11 [9-13] vs 16 [12-20]天; P =.001）。
Abstract The viral RNA shedding time (VST) for severe acute respiratory syndrome coronavirus 2 has not been well characterized. Clinical data were collected and compared between patients with short and long VSTs (in the lower and upper quartiles, respectively). The probability of recurrent positive reverse-transcription polymerase chain reaction results decreased sharply to 4.8% after 3 consecutive negative results. A series of ≥3 consecutive negative results was suitable as a criterion for the end of viral RNA shedding. The VST for shedding from the respiratory tract was significantly shorter in patients with normal B-cell counts on admission than in those with decreased B-cell counts (median [interquartile range], 11 [9–13] vs 16 [12–20] days, respectively; P = .001).