Connections Between Obesity and Puberty: Invited by Manuel Tena-Sempere, Cordoba.
Connections Between Obesity and Puberty: Invited by Manuel Tena-Sempere, Cordoba.
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DOI：
10.1016/j.coemr.2020.08.004
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发表时间：
2020-10
影响因子：
--
通讯作者：
Roth CL
中科院分区：
文献类型：
--
作者：
Huang A;Reinehr T;Roth CL
肥胖和青春期之间的关系仍然存在争议。横向和纵向研究显示，肥胖女孩的青春期明显提前，而肥胖男孩的趋势仍然不太明显。与健康体重的男孩相比，超重的男孩成熟得早，而肥胖的男孩成熟得晚。较新的流行病学研究试图解决这些知识差距。这篇综述提供了一个详细的概述，最近的文献中关于青春期的开始和克里思的长期趋势，并与肥胖的连接。此外，这篇综述总结了潜在的介质，允许肥胖，以促进青春期提前。其他因素，如社会经济地位、子宫内接触、营养、甚至干扰内分泌的化学品，都可能引起新陈代谢和内分泌轴的紊乱，最终影响青春期发育。
The relationship between obesity and puberty remains controversial. Whereas cross-sectional and longitudinal studies show a clear shift toward earlier puberty in obese girls, the trend in obese boys remains less obvious. Overweight boys mature earlier whereas obese boys mature later compared to healthy weight boys. Newer epidemiologic studies attempt to address these knowledge gaps. This review provides a detailed overview of the recent literature regarding secular trends in pubertal onset and tempo, and the connection with obesity. Additionally, this review summarizes potential mediators that permit obesity to promote early puberty. Other factors such as socioeconomic status, in utero exposures, nutritional, and even endocrine disrupting chemicals can cause perturbation of both metabolism and the endocrine axis that can ultimately have effects on pubertal development.