Reduce, Induce, Thrive: Bacterial Redox Sensing during Pathogenesis.
Reduce, Induce, Thrive: Bacterial Redox Sensing during Pathogenesis.
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DOI：
10.1128/jb.00128-18
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发表时间：
2018-09-01
影响因子：
3.2
通讯作者：
Reniere ML
中科院分区：
文献类型：
--
作者：
Reniere ML
氧化剂和还原剂的丰富度必须保持平衡，有机体才能茁壮成长。细菌已经进化出了防止氧化还原失衡的方法，并通过表达解毒酶、抗氧化剂以及修复或降解受损蛋白质和 DNA 的系统来减轻其有害后果。氧化剂和还原剂的丰富度必须保持平衡，有机体才能茁壮成长。细菌已经进化出了防止氧化还原失衡的方法，并通过表达解毒酶、抗氧化剂以及修复或降解受损蛋白质和 DNA 的系统来减轻其有害后果。调节这些过程以响应氧化还原变化需要复杂的监视策略，从金属螯合到直接传感有毒活性氧。就细菌病原体而言，威胁破坏氧化还原稳态的应激可能来自内源性来源（由细菌产生）或外源性来源（由宿主产生）。这篇小综述总结了感染过程中遇到的氧化还原应激的来源、细菌病原体减少氧化还原应激破坏性影响的机制，以及一些生物体在感染过程中面对氧化还原挑战时进化出的聪明的方式。
The abundance of oxidants and reductants must be balanced for an organism to thrive. Bacteria have evolved methods to prevent redox imbalances and to mitigate their deleterious consequences through the expression of detoxification enzymes, antioxidants, and systems to repair or degrade damaged proteins and DNA. The abundance of oxidants and reductants must be balanced for an organism to thrive. Bacteria have evolved methods to prevent redox imbalances and to mitigate their deleterious consequences through the expression of detoxification enzymes, antioxidants, and systems to repair or degrade damaged proteins and DNA. Regulating these processes in response to redox changes requires sophisticated surveillance strategies ranging from metal chelation to direct sensing of toxic reactive oxygen species. In the case of bacterial pathogens, stress that threatens to disrupt redox homeostasis can derive from endogenous sources (produced by the bacteria) or exogenous sources (produced by the host). This minireview summarizes the sources of redox stress encountered during infection, the mechanisms by which bacterial pathogens diminish the damaging effects of redox stress, and the clever ways some organisms have evolved to thrive in the face of redox challenges during infection.