Role of intravital imaging in nanomedicine-assisted anti-cancer therapy
Role of intravital imaging in nanomedicine-assisted anti-cancer therapy
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DOI：
10.1016/j.copbio.2020.12.024
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Honglin Jin
中科院分区：
文献类型：
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作者：
Lisen Lu;Yajie Sun;Chao Wan;Yan Hu;Pui-Chi Lo;Lovell Jonathan F;Kunyu Yang;Honglin Jin
Although nanomedicines have provided promising anti-tumoreffects in cancer animal models, their clinical success remainslimited. One of the most significant barriers in the clinicaltranslation of nanomedicines is that they consist of multiplecomponents, each of which may have different toxicities andtherapeutic effects. Intravital imaging provides high spatial andtemporal resolution for visualizing nanomedicine-mediatedinteractions between immune cells and tumor cells in real-time.Intravital imaging can facilitate the in vivo evaluation of theproperties and effects of nanomedicines, such as their ability tocross the tumor vasculature, specifically eliminate the cancercells, and modulate the immune cells found in the tumormicroenvironment (TME). Thus, intravital imaging can providedirect evidence of nanomedicine’s intravital behavior to betterunderstand mechanism and accelerate clinical translation. Inthis review, we summarize several applications and latestadvances in intravital imaging in nanomedicine-assisted anti-cancer therapy and discuss future perspectives in the field.
