mTOR Signaling in the Regulation of CD4+ T Cell Subsets in Periodontal Diseases.
mTOR Signaling in the Regulation of CD4+ T Cell Subsets in Periodontal Diseases.
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DOI：
10.3389/fimmu.2022.827461
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发表时间：
2022
影响因子：
7.3
通讯作者：
Chen C
中科院分区：
文献类型：
--
作者：
Jiang Q;Huang X;Yu W;Huang R;Zhao X;Chen C
牙周病是由微生物群落的炎症浸润引起的，这是通过牙齿的活动和牙槽骨吸收来标志的。牙周病炎症是由CD4+ T细胞通过细胞因子分泌和破骨细胞发生活性介导的。从历史上看，牙周病的炎症模型是通过破坏T辅助细胞的两个亚群之间的平衡来描述的，这两个亚群是T辅助1型（Th1）和T辅助2型（Th2）。然而，越来越多的研究发现，除了辅助性T细胞亚群外，调节性T细胞和Th17细胞也参与了牙周病的发病。越来越多的证据表明，辅助性T细胞的分化、激活和亚群的确定都受到mTOR信号的强烈影响。mTOR信号可以通过不同的mTOR复合物促进Th1和Th17细胞分化，抑制Treg承诺，因此我们预计mTOR信号通过调节CD4+ T细胞亚群对牙周病的调节作用。本文就不同类型的Th细胞在牙周病发病中的作用，以及mTOR信号在Th细胞承诺的规范和选择中的调控等方面的研究进展进行综述。
Periodontal disease results from the inflammatory infiltration by the microbial community which is marked through tooth mobility and alveolar bone resorption. The inflammation in periodontal disease is mediated by CD4+ T cells through cytokine secretion and osteoclastogenetic activity. Historically, the inflammatory model in periodontal disease is described through disruption of the balance between two subsets of T helper cells which are T-helper type 1 (Th1) and T-helper type 2 (Th2). However, more and more studies have found that apart from subsets of helper T cells, regulatory T-cells and Th17 cells are also involved in the pathogenesis of periodontal diseases. Growing evidence proves that helper T cells differentiation, activation, and subset determination are under the strong impact of mTOR signaling. mTOR signaling could promote Th1 and Th17 cell differentiation and inhibit Treg commitment through different mTOR complexes, therefore we anticipate a regulation effect of mTOR signaling on periodontal diseases by regulating CD4+ T cell subsets. This review aims to integrate the topical researches about the role of different types of Th cells in the pathogenesis of periodontal diseases, as well as the regulation of mTOR signaling in the specification and selection of Th cell commitment.