Spatial and temporal patterns of Zaire ebolavirus antibody prevalence in the possible reservoir bat species
Spatial and temporal patterns of Zaire ebolavirus antibody prevalence in the possible reservoir bat species
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DOI：
10.1086/520541
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发表时间：
2007-11-15
影响因子：
6.4
通讯作者：
Leroy, E. M.
中科院分区：
文献类型：
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作者：
Pourrut, X.;Delicat, A.;Leroy, E. M.
为了表征扎伊尔埃博拉病毒（ZEBOV）感染的分布在3蝙蝠物种（Epomops franqueti，Hypsignathus monstrosus，Myonycteris torquata），可能的水库，我们收集了1390蝙蝠在2003-2006年在加蓬和刚果共和国。在40个样本中检测到ZEBOV免疫球蛋白G（IgG）支持这些蝙蝠物种作为ZEBOV储库的作用。ZEBOV IgG流行率（5%）在疫情期间流行和非流行地区是同质的，表明受感染的蝙蝠很可能存在于中非的非流行地区。ZEBOV IgG流行率在爆发后显著下降至1%，表明IgG阳性蝙蝠的百分比与病毒传播至其他动物物种和爆发外观有关。大量ZEBOV IgG阳性的成年蝙蝠和妊娠H. monstrosus females表明蝙蝠种群通过争斗和性接触传播病毒。因此，我们的研究有助于描述埃博拉病毒在蝙蝠中的传播，并对疫情的出现提供了一些见解。
To characterize the distribution of Zaire ebolavirus (ZEBOV) infection within the 3 bat species (Epomops franqueti, Hypsignathus monstrosus, and Myonycteris torquata) that are possible reservoirs, we collected 1390 bats during 2003-2006 in Gabon and the Republic of the Congo. Detection of ZEBOV immunoglobulin G (IgG) in 40 specimens supports the role of these bat species as the ZEBOV reservoirs. ZEBOV IgG prevalence rates (5%) were homogeneous across epidemic and nonepidemic regions during outbreaks, indicating that infected bats may well be present in nonepidemic regions of central Africa. ZEBOV IgG prevalence decreased, significantly, to 1% after the outbreaks, suggesting that the percentage of IgG-positive bats is associated with virus transmission to other animal species and outbreak appearance. The large number of ZEBOV IgG-positive adult bats and pregnant H. monstrosus females suggests virus transmission within bat populations through fighting and sexual contact. Our study, thus, helps to describe Ebola virus circulation in bats and offers some insight into the appearance of outbreaks.