Ongoing change of severe hand, foot, and mouth disease pathogens in Yunnan, China, 2012 to 2016
Ongoing change of severe hand, foot, and mouth disease pathogens in Yunnan, China, 2012 to 2016
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DOI：
10.1002/jmv.25393
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发表时间：
2019-05-01
影响因子：
12.7
通讯作者：
Ma, Shaohui
中科院分区：
文献类型：
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作者：
Du, Zengqing;Zhao, Yilin;Ma, Shaohui
手足口病（手足口病）是一种由肠道病毒引起的常见传染病。本研究选取2012 - 2016年云南省某儿科医院收治的341例重度手足口病患儿。检出EVs 283份（83.0%），分为17种EVs类型。以肠病毒A71型（EV-A71）为主，占41.6%，其次为柯萨奇病毒A16型（CV-A16 18.8%）、CV-A6型（9.1%）、CV-A10和E-9型（2.9%）、CV-B5型（1.8%）、CV-A9型（1.2%）、E-30型（0.9%）、E-18型、CV-A4型、C-B3型和CV-A2型（0.6%）以及CV-A8、CV-A14、E-14、E-11和CV-B4型（0.3%）。所有EV-A71分离株均属C4a型；CV-A16属B1b或B1a型，但以B1b型为主；CV-A6属于D3。2012 - 2014年，E-9型为第三常见血清型（分别为8.2%、5.0%和6.5%）。E-9在2015年和2016年没有被发现。2012年未检测到CV-A6，但在2015年是第二常见的血清型（25.3%）。手足口病的主动病原学监测使得有必要了解这些新出现的病原体。
Hand, foot, and mouth disease (HFMD) is a common infectious disease caused by enteroviruses (EVs). In this study, a total of 341 children with serious HFMD were admitted to a pediatric hospital in Yunnan, China in 2012 to 2016. EVs were detected in 283 specimens (83.0%) and were assigned to 17 EV types. Enterovirus A71 (EV-A71) was predominant, accounting for 41.6%, and was followed by coxsackievirus A16 (CV-A16; 18.8%), CV-A6 (9.1%), CV-A10 and E-9 (2.9%), CV-B5 (1.8%), CV-A9 (1.2%), E-30 (0.9%), E-18, CV-A4, C-B3, and CV-A2 (0.6%) and other EV types such as CV-A8, CV-A14, E-14, E-11, and CV-B4 (0.3%). All of the EV-A71 isolates belonged to C4a; the CV-A16 belonged to B1b or B1a, although the B1b strains were predominant; and CV-A6 belonged to D3. In 2012 to 2014, E-9 was the third most frequent serotype (8.2%, 5.0%, and 6.5%, respectively). E-9 was not detected in 2015 and 2016. CV-A6 was not detected in 2012 but was the second most frequent serotype (25.3%) in 2015. Active etiological surveillance of HFMD makes it necessary to be aware of these emerging pathogens.