Mechanisms influencing stimulus-response properties of the human corticospinal system
Mechanisms influencing stimulus-response properties of the human corticospinal system
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DOI：
10.1016/s1388-2457(01)00523-5
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发表时间：
2001-05-01
影响因子：
4.7
通讯作者：
Cohen, LG
中科院分区：
文献类型：
--
作者：
Boroojerdi, B;Battaglia, F;Cohen, LG
背景资料：人类皮质脊髓系统的刺激-反应（S-R）特性取决于皮质脊髓通路沿着不同部位发生的相互作用。经颅磁刺激（TMS）引起的刺激-反应曲线的影响机制及其沿人神经轴的沿着操作部位知之甚少。在这项研究中，我们研究了具有不同作用机制的CNS活性药物对S-R曲线的影响。这些药物中的每一种对S-R曲线的影响将指向特定机制的参与。此外，S-R曲线的相对敏感性与其他措施相比，皮质脊髓excitability studied.Methods：我们研究了劳拉西泮，这是一个积极的别构调节剂的GABAA受体，拉莫三嗪，抑制剂的电压门控Na+和Ca ~（2+）通道，和D-安非他明，多巴胺能-肾上腺素能系统的间接激动剂，对S-R曲线，运动阈值（MT），皮质内抑制（ICI）和皮质内易化（ICF）。最大外周M反应和F波进行了研究，作为措施的总CR-运动神经元池和其excitability.Results：F和M波不受药物或安慰剂。劳拉西泮和拉莫三嗪均使S-R曲线明显下降，但不改变ICI和ICF。D-苯丙胺使S-R曲线和ICF均增强。结论：S-R曲线受GABA能和单胺能系统以及Na+和Ca ~（2+）通道特性的影响。结果表明，在运动系统兴奋性的不同参数中，S-R曲线最为敏感。(C)2001爱思唯尔科学爱尔兰有限公司保留所有权利。
Background: Stimulus-response (S-R) properties of the corticospinal system in humans depend on the interactions that take place at different sites along the corticospinal pathway. The mechanisms influencing stimulus-response curves elicited by transcranial magnetic stimulation (TMS) and their operation site along the human neuraxis are poorly understood. In this study, we investigated the effects of CNS-active drugs with distinct mechanisms of action on S-R curves. Effects of each of these drugs on S-R curves would point to the involvement of specific mechanisms. Additionally, relative sensitivity of S-R curves compared with other measures of corticospinal excitability was studied.Methods: We studied the effects of lorazepam, which is a positive allosteric modulator of GABAA receptors; lamotrigine, an inhibitor of voltage-gated Na+ and Ca2+ channels; and D-amphetamine, an indirect agonist of the dopaminergic-adrenergic system on S-R curves, motor thresholds (MT), and intracortical inhibition (ICI) and facilitation (ICF) with a double-pulse technique. Maximum peripheral M responses and F waves were investigated as measures of the total cr-motoneuron pool and its excitability.Results: F and M waves were unaffected by either the drugs or placebo. S-R curves were significantly depressed by lorazepam and lamotrigine without changes in ICI and ICF. Both S-R curves and ICF were enhanced by D-amphetamine. MT increased only with lamotrigine.Conclusions: S-R curves were influenced by changes in the GABAergic and monoaminergic system and Na+ and Ca2+ channel properties. Our results indicate that, out of different parameters of motor system excitability, S-R curves were the most sensitive. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.