Early interfaced neural activity from chronic amputated nerves.
Early interfaced neural activity from chronic amputated nerves.
复制标题
DOI：
10.3389/neuro.16.005.2009
复制
发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Romero MI
中科院分区：
文献类型：
--
作者：
Garde K;Keefer E;Botterman B;Galvan P;Romero MI
将切断的周围神经与先进的机器人假体设备直接对接，被认为是实现这种仿生替代品的自然运动控制和感觉感知的一种策略，从而完全功能地修复截肢者的肢体缺失。放置在大脑和周围神经中的多电极阵列已成功地用于将假肢设备的神经控制传递给用户。然而，反应性胶质增生、微小出血、轴索病变和过度炎症目前限制了它们的长期使用。在这里，我们证明，无论是急性或慢性神经切断后，通过非梗阻性多电极阵列诱导周围神经再生，为获得早期神经记录和加强神经活动的长期对接提供了一种可行的替代方案。放置在再生神经纤维通路上的非限制性电极阵列允许早在植入后8 天就记录到高信噪比的动作电位，在某些动物中长达3 月，并且神经组织-金属电极界面的炎症最小。我们的发现表明，开放式设计的再生多电极阵列允许来自被切断的周围神经的神经活动的早期和稳定的对接，并可能有助于向机器人假肢设备的使用者传达完全的神经控制和感觉反馈。
Direct interfacing of transected peripheral nerves with advanced robotic prosthetic devices has been proposed as a strategy for achieving natural motor control and sensory perception of such bionic substitutes, thus fully functionally replacing missing limbs in amputees. Multi-electrode arrays placed in the brain and peripheral nerves have been used successfully to convey neural control of prosthetic devices to the user. However, reactive gliosis, micro hemorrhages, axonopathy and excessive inflammation currently limit their long-term use. Here we demonstrate that enticement of peripheral nerve regeneration through a non-obstructive multi-electrode array, after either acute or chronic nerve amputation, offers a viable alternative to obtain early neural recordings and to enhance long-term interfacing of nerve activity. Non-restrictive electrode arrays placed in the path of regenerating nerve fibers allowed the recording of action potentials as early as 8 days post-implantation with high signal-to-noise ratio, as long as 3 months in some animals, and with minimal inflammation at the nerve tissue-metal electrode interface. Our findings suggest that regenerative multi-electrode arrays of open design allow early and stable interfacing of neural activity from amputated peripheral nerves and might contribute towards conveying full neural control and sensory feedback to users of robotic prosthetic devices.