Anal human papillomavirus infection is associated with HIV acquisition in men who have sex with men.
Anal human papillomavirus infection is associated with HIV acquisition in men who have sex with men.
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肛门人乳头瘤病毒感染与与男性发生性关系的男性中的艾滋病毒获取有关。
DOI：
10.1097/qad.0b013e32832b4449
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发表时间：
2009-06-01
期刊：
影响因子：
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通讯作者：
Palefsky JM
中科院分区：
文献类型：
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作者：
Chin-Hong PV;Husnik M;Cranston RD;Colfax G;Buchbinder S;Da Costa M;Darragh T;Jones D;Judson F;Koblin B;Mayer KH;Palefsky JM
人乳头瘤病毒（HPV）是一种常见的性传播媒介，可引起肛门生殖器癌和癌前病变，这些病变具有炎症浸润，可能是脆弱的和出血的。我们的目的是确定肛门HPV感染和HIV获得之间的关联。前瞻性队列研究。我们从波士顿、丹佛、纽约和弗朗西斯科的社区环境中招募了1409名HIV阴性的男男性行为者。我们使用考克斯比例风险回归模型，评估HPV感染与HIV感染率的独立相关性。在1409名参与者中，有4375人-年的随访，51名艾滋病毒血清转化。在HIV血清转换时，HPV感染的HIV血清转换者中HPV型别的中位数为2（四分位数间距1-3）。在对性活动、物质使用、其他性传播感染的发生率和人口统计学变量进行调整后，有证据（P = 0.002）表明感染至少两种HPV类型（风险比3.5，95%置信区间1.2-10.6）对HIV血清转换有影响。肛门HPV感染与HIV获得独立相关。需要结合高分辨率肛门镜检查来更准确地识别HPV相关疾病的研究，以确定HPV相关疾病和HIV血清转换之间的关系。
Human papillomavirus (HPV) is a common sexually transmitted agent that causes anogenital cancer and precancer lesions that have an inflammatory infiltrate, may be friable and bleed. Our aim was to determine the association between anal HPV infection and HIV acquisition. A prospective cohort study. We recruited 1409 HIV-negative men who have sex with men recruited from a community-based setting in Boston, Denver, New York and San Francisco. We used Cox proportional hazards regression modeling and assessed the independent association of HPV infection with the rate of acquisition of HIV infection. Of 1409 participants contributing 4375 person-years of follow-up, 51 HIV-seroconverted. The median number of HPV types in HPV-infected HIV-seroconverters was 2 (interquartile range 1–3) at the time of HIV seroconversion. After adjustment for sexual activity, substance use, occurrence of other sexually transmitted infections and demographic variables, there was evidence (P░=░0.002) for the effect of infection with at least two HPV types (hazard ratio 3.5, 95% confidence interval 1.2–10.6) in HIV seroconversion. Anal HPV infection is independently associated with HIV acquisition. Studies that incorporate high-resolution anoscopy to more accurately identify HPV-associated disease are needed to determine the relationship between HPV-associated disease and HIV seroconversion.