A Strategy for the Targeting of Photosensitizers. Synthesis, Characterization, and Photobiological Property of Porphyrins Bearing Glycodendrimeric Moieties
A Strategy for the Targeting of Photosensitizers. Synthesis, Characterization, and Photobiological Property of Porphyrins Bearing Glycodendrimeric Moieties
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DOI：
10.1021/jo102185d
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发表时间：
2011-04-01
影响因子：
3.6
通讯作者：
Maillard, Philippe
中科院分区：
文献类型：
--
作者：
Ballut, Severine;Naud-Martin, Delphine;Maillard, Philippe
本文介绍了新的四吡咯生色团的概念，合成和表征的糖树枝状部分诱导的集群效应的肿瘤靶向的潜在增加。两个家庭的monoglycodendrimic光敏剂轴承三个糖基单元的设计，制备具有可接受的整体效率，其特征在于，通过NMR，UV-可见光，和荧光光谱。极性和log P分别通过HPLC和搅拌烧瓶法进行评价。评估了针对两种人肿瘤细胞系的体外光效率。糖树枝状聚合物基团的存在似乎不会增加体外靶向肿瘤。
This paper describes the conception, synthesis, and characterization of new tetrapyrrolic chromophores bearing glycodendrimeric moieties inducing a potential increase of tumor targeting by a cluster effect. Two families of monoglycodendrimeric photosensitizers bearing three glycosyl units were designed, prepared with an acceptable overall efficiency and characterized by NMR, UV-visible, and fluorescence spectroscopies. The polarity and log P were evaluated by HPLC and the stir-flask method, respectively. The in vitro photoefficiency against two human tumor cell lines was assessed. The presence of the glycodendrimeric group does not appear to increase the tumor in vitro targeting.