Magnesium intake is related to improved insulin homeostasis in the framingham offspring cohort
Magnesium intake is related to improved insulin homeostasis in the framingham offspring cohort
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DOI：
10.1080/07315724.2006.10719563
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发表时间：
2006-12-01
影响因子：
3.5
通讯作者：
Jacques, Paul F.
中科院分区：
文献类型：
--
作者：
Rumawas, Marcella E.;McKeown, Nicola M.;Jacques, Paul F.
目的：较高的膳食镁摄入量可预防2型糖尿病的发生。本研究的目的是研究膳食镁摄入量与糖尿病代谢危险因素之间的关系。方法：我们在Framingham子代队列中对1223名男性和1485名女性的饮食镁摄入量与空腹血糖和胰岛素、挑战后2小时血糖和胰岛素以及稳态模型(HOMA-IR)评估的胰岛素抵抗之间的横向关联进行了研究。镁的摄入量通过食物频率问卷进行评估，镁的摄入量被归类为五分之一的类别。结果：在调整潜在的混杂因素后，镁摄入量与空腹胰岛素(最低摄入量与最高摄入量的平均值：29.9vs26.7mU/mL；P趋势与lt；0.001)、糖化后的血浆胰岛素(86.4vs72mU/mL；P趋势与lt；0.001)以及HOMA-IR(7.0vs6.2；P趋势与lt；0.001)呈负相关。0.001)。镁摄入量与空腹血糖和餐后2小时血糖无明显相关性。结论：改善胰岛素敏感性可能是膳食镁摄入量增加降低2型糖尿病发病风险的机制之一。
Objective: Higher dietary intake of magnesium may protect against development of type 2 diabetes. The aim of this study was to examine the association between dietary magnesium intake and metabolic risk factors for diabetes.Methods: We examined cross-sectional associations between magnesium intake and fasting glucose and insulin, 2-hour post-challenge plasma glucose and, insulin, and insulin resistance assessed by the homeostasis model (HOMA-IR) in 1223 men and 1485 women without diabetes from the Framingham Offspring cohort. Magnesium intake was assessed by a food frequency questionnaire and magnesium intake was categorized into quintile categories. Geometric mean insulin, glucose, 2-hour post challenge plasma glucose and insulin concentrations and HOMA-IR were estimated across quintile categories of magnesium intake using Generalized Linear Models.Results: After adjustment for potential confounding factors, magnesium intake was inversely associated with fasting insulin (mean: 29.9 vs 26.7 mu U/mL in the lowest vs highest quintiles of magnesium intake; P trend < 0.001), post-glucose challenge plasma insulin (86.4 vs 72 mu U/mL; P trend < 0.001), and HOMA-IR (7.0 vs 6.2; P trend < 0.001). No significant association was found between magnesium intake and fasting glucose or 2-hour post challenge glucose.Conclusions: Improved insulin sensitivity may be one mechanism by which higher dietary magnesium intake may reduce the risk of developing type 2 DM.