TRAUMATIC RETINOPATHY IN PRIMATES - EXPLANATION OF COMMOTIO RETINAE
TRAUMATIC RETINOPATHY IN PRIMATES - EXPLANATION OF COMMOTIO RETINAE
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DOI：
10.1001/archopht.1978.03910060563021
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发表时间：
1978-01-01
影响因子：
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通讯作者：
GASS, JDM
中科院分区：
文献类型：
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作者：
SIPPERLEY, JO;QUIGLEY, HA;GASS, JDM
对12只猫头鹰猴钝性损伤后视网膜产生的实验性骚动进行了研究。检眼镜和荧光素血管造影显示，这种结缔组织病变与人类急性创伤性视网膜混浊相同。损伤后4 h ~ 12周用光镜和电镜观察。损伤后，唯一的异常是受体外段的破坏。创伤后1-6天，许多受体细胞发生变性。视网膜色素上皮吞噬退化的外节，偶尔向视网膜内迁移。无细胞外视网膜水肿。视网膜紊乱的不透明似乎代表了受体细胞的破坏。永久性丧失感受器可能导致视力丧失。色素上皮对创伤性受体损伤的反应与实验性视网膜脱离和光致视网膜损伤的反应相似。
Experimental commotio retinae was produced in 12 owl monkeys [Aotus trivirgatus] by blunt trauma. The ophthalmoscopic and fluorescein angiographic appearance of this contrecoup lesion is identical to the acute traumatic retinal opacity in humans. These eyes were examined by light microscopy and EM from 4 h to 12 wk after injury. Immediately after injury, the only abnormality is disruption of the receptor outer segments. From 1-6 days after trauma, many receptor cells undergo degeneration. The retinal pigment epithelium phagocytoses the degenerating outer segments, occasionally migrating into the retina. There is no extracellular retinal edema. The opacity of commotio retinae seems to represent disrupted receptor cells. Visual loss may result from permanent loss of receptors. The pigment epithelial response to traumatic receptor damage is similar to that observed in experimental retinal detachment and light-induced retinal damage.