Oxidative stress, NADPH oxidases, and arteries.
Oxidative stress, NADPH oxidases, and arteries.
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DOI：
10.5482/hamo-14-11-0076
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发表时间：
2016-05-10
期刊：
影响因子：
3.2
通讯作者：
Madamanchi NR
中科院分区：
文献类型：
--
作者：
Sun QA;Runge MS;Madamanchi NR
动脉粥样硬化及其主要并发症——心肌梗死和中风——仍然是美国和全世界死亡和残疾的主要原因。事实上，随着肥胖和糖尿病的急剧增加，心血管疾病的患病率和公共卫生影响可能会保持在高位。在降低动脉粥样硬化和心血管疾病发病率的新疗法开发方面取得了重大进展，特别是在治疗高胆固醇血症和高血压方面。氧化应激是许多心血管疾病危险因素的共同机制联系。然而，直到最近才有工具在动物模型中研究氧化应激和CVD之间的界面。血管细胞中活性氧最重要的来源是多种形式的酶——烟酰胺腺嘌呤二核苷酸磷酸氧化酶（NADPH氧化酶）。最近发表的和新出现的研究清楚地表明：1)动物模型中NADPH氧化酶在动脉粥样硬化和高血压中起着至关重要的作用；2)考虑到NADPH氧化酶关键组分的组织特异性表达，可能有可能针对血管氧化应激来预防CVD。
Atherosclerosis and its major complications –myocardial infarction and stroke– remain major causes of death and disability in the United States and world-wide. Indeed, with dramatic increases in obesity and diabetes mellitus, the prevalence and public health impact of cardiovascular diseases (CVD) will likely remain high. Major advances have been made in development of new therapies to reduce the incidence of atherosclerosis and CVD, in particular for treatment of hypercholesterolemia and hypertension. Oxidative stress is the common mechanistic link for many CVD risk factors. However, only recently have the tools existed to study the interface between oxidative stress and CVD in animal models. The most important source of reactive oxygen species (and hence oxidative stress) in vascular cells are the multiple forms of enzymes nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase). Recently published and emerging studies now clearly establish that: 1) NADPH oxidases are of critical importance in atherosclerosis and hypertension in animal models; 2) given the tissue-specific expression of key components of NADPH oxidase, it may be possible to target vascular oxidative stress for prevention of CVD.