Human leukocyte antigen class I alleles and haplotypes associated with primary hepatocellular carcinoma in persistent HBV-infected patients
Human leukocyte antigen class I alleles and haplotypes associated with primary hepatocellular carcinoma in persistent HBV-infected patients
复制标题
人类白细胞抗原 I 类等位基因和单倍型与持续性 HBV 感染患者的原发性肝细胞癌相关
DOI：
10.1016/j.humimm.2013.02.007
复制
发表时间：
2013-06-01
期刊：
影响因子：
2.7
通讯作者：
Zhang, Jianqiong
中科院分区：
文献类型：
--
作者：
Pan, Ning;Chen, Keping;Zhang, Jianqiong
许多研究表明，人类白细胞抗原（HLA）I 类等位基因与各种癌症的发生有关。然而，其在肝细胞癌（HCC）中的作用仍不清楚。为了调查 HLA I 类等位基因多态性是否与乙型肝炎病毒 (HBV) 相关 HCC 的发生有关，本研究共纳入了 326 名 HBV 感染患者（138 名患有 HCC 的个体和 188 名匹配的无 HCC 的对照者）。通过聚合酶链式反应-测序分型（PCR-SBT）方法对HLA-A、-B和-C进行基因分型。我们将 HLA-B*35:01:01G 确定为 HBV 相关 HCC 发展的危险因素，与我们之前在 HLA 区域的发现无关（OR，12.04；p，0.0028；pc，0.04）。 HLA-A*11:01:01G、B*58:01:01G、C*03:02:01G 及其一些扩展单倍型被发现是 HCC 发展的潜在易感因素。 HLA-B*46:01:01G 及其一些扩展单倍型被发现是 HCC 发展的潜在保护因素。我们的结果支持特定 HLA I 类等位基因和单倍型可能影响 HBV 相关 HCC 发展的风险。这些发现可能有助于确定预防和治疗这些患者 HCC 的更好方法。 (c) 2013 年美国组织相容性和免疫遗传学学会。由爱思唯尔公司出版。保留所有权利。
Many studies have shown that Human leukocyte antigen (HLA) class I alleles are associated with the development of various cancers. However, its role in hepatocellular carcinoma (HCC) is still unknown. To investigate whether HLA class I allelic polymorphism is related to the development of hepatitis B virus(HBV)-associated HCC, a total of 326 HBV-infected patients (138 individuals with HCC and 188 well-matched controls without HCC) were enrolled in this study. HLA-A, -B, and -C were genotyped by polymerase chain reaction-sequencing based typing (PCR-SBT) method. We identified HLA-B*35:01:01G as a risk factor for HBV-related HCC development independent of our previous findings in HLA region (OR, 12.04; p, 0.0028; pc, 0.04). HLA-A*11:01:01G, B*58:01:01G, C*03:02:01G and some of their extended haplotypes were found as potential susceptible factors for HCC development. HLA-B*46:01:01G and some of its extended haplotypes were found as potential protective factors for HCC development. Our results support that specific HLA class I alleles and haplotypes may affect the risk of HBV-related HCC development. The findings may help to determine better approaches for prevention and treatment of HCC in these patients. (c) 2013 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.