The COVID-19 nephrology compendium: AKI, CKD, ESKD and transplantation.

The COVID-19 nephrology compendium: AKI, CKD, ESKD and transplantation.
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COVID-19肾脏病纲要:AKI,CKD,ESKD和移植。

DOI:
10.1186/s12882-020-02112-0
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发表时间:
2020-10-27
期刊:
影响因子:
2.3
通讯作者:
Jaar BG
Jaar BG
中科院分区:
医学4区
文献类型:
--
作者:
Kant S;Menez SP;Hanouneh M;Fine DM;Crews DC;Brennan DC;Sperati CJ;Jaar BG

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2019冠状病毒病(COVID-19)大流行是一个前所未有的时期。该疾病影响多个器官系统,急性肾损伤(阿基)是重症患者的主要并发症。在众多国际研究中,COVID-19患者的阿基发生率各不相同,但在重症监护环境中阿基的高发生率及其相关的更差结局是一致的发现。阿基的多种模式和机制已被阐明,并已实施解决肾脏替代治疗设备短缺的新策略。该疾病还对慢性肾病和终末期肾病患者的纵向管理产生了影响。由于免疫抑制,肾移植受者可能特别容易感染COVID-19,初步研究表明死亡率很高。建议在疾病急性期加强对低阈值疾病的监测,并调整免疫抑制方案。
The pandemic of coronavirus disease 2019 (CoVID-19) has been an unprecedented period. The disease afflicts multiple organ systems, with acute kidney injury (AKI) a major complication in seriously ill patients. The incidence of AKI in patients with CoVID-19 is variable across numerous international studies, but the high incidence of AKI and its associated worse outcomes in the critical care setting are a consistent finding. A multitude of patterns and mechanisms of AKI have been elucidated, and novel strategies to address shortage of renal replacement therapy equipment have been implemented. The disease also has had consequences on longitudinal management of patients with chronic kidney disease and end stage kidney disease. Kidney transplant recipients may be especially susceptible to CoVID-19 as a result of immunosuppression, with preliminary studies demonstrating high mortality rates. Increased surveillance of disease with low threshold for testing and adjustment of immunosuppression regimen during acute periods of illness have been recommended.
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