Alcohol Consumption and Risk of Postmenopausal Breast Cancer by Subtype: The Women's Health Initiative Observational Study
Alcohol Consumption and Risk of Postmenopausal Breast Cancer by Subtype: The Women's Health Initiative Observational Study
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DOI：
10.1093/jnci/djq316
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发表时间：
2010-09-01
期刊：
影响因子：
--
通讯作者：
Prentice, Ross
中科院分区：
文献类型：
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作者：
Li, Christopher I.;Chlebowski, Rowan T.;Prentice, Ross
背景饮酒是乳腺癌的一个公认的危险因素。这种关联被认为主要是由酒精驱动的，因此酒精使用可能与对酒精敏感的乳腺癌有更强的关联。很少有研究评估酒精相关的风险如何不同的乳腺癌subtype.Methods自我报告的饮酒量和绝经后乳腺癌的风险之间的关系进行了评估，87 724名妇女在妇女的健康倡议观察性研究前瞻性队列从1993年到1998年。采用多变量校正的考克斯回归模型计算风险比（HR）和95%置信区间（CI）。所有的统计学检验是双侧的。结果共2944浸润性乳腺癌患者被诊断为随访期间至2005年9月15日。在多变量校正分析中，饮酒与总体浸润性乳腺癌、浸润性小叶癌和激素受体阳性肿瘤的风险呈正相关（均P <0.05）。
Background Alcohol consumption is a well-established risk factor for breast cancer. This association is thought to be largely hormonally driven, so alcohol use may be more strongly associated with hormonally sensitive breast cancers. Few studies have evaluated how alcohol-related risk varies by breast cancer subtype.Methods We assessed the relationship between self-reported alcohol consumption and postmenopausal breast cancer risk among 87 724 women in the Women's Health Initiative Observational Study prospective cohort from 1993 through 1998. Multivariable adjusted Cox regression models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). All statistical tests were two-sided.Results A total of 2944 invasive breast cancer patients were diagnosed during follow-up through September 15, 2005. In multivariable adjusted analyses, alcohol consumption was positively related to risk of invasive breast cancer overall, invasive lobular carcinoma, and hormone receptor-positive tumors (all P(trend)