Can GLP-1 Be a Target for Reward System Related Disorders? A Qualitative Synthesis and Systematic Review Analysis of Studies on Palatable Food, Drugs of Abuse, and Alcohol.
Can GLP-1 Be a Target for Reward System Related Disorders? A Qualitative Synthesis and Systematic Review Analysis of Studies on Palatable Food, Drugs of Abuse, and Alcohol.
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GLP-1能成为奖励系统相关障碍的靶点吗？可口食品、滥用药物和酒精研究的定性综合和系统回顾分析。
DOI：
10.3389/fnbeh.2020.614884
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发表时间：
2020
影响因子：
3
通讯作者：
Yapici-Eser H
中科院分区：
文献类型：
--
作者：
Eren-Yazicioglu CY;Yigit A;Dogruoz RE;Yapici-Eser H
The role of glucagon-like peptide 1 (GLP-1) in insulin-dependent signaling is well-known; GLP-1 enhances glucose-dependent insulin secretion and lowers blood glucose in diabetes. GLP-1 receptors (GLP-1R) are also widely expressed in the brain, and in addition to its role in neuroprotection, it affects reward pathways. This systematic review aimed to analyze the studies on GLP-1 and reward pathways and its currently identified mechanisms. Methods: “Web of Science” and “Pubmed” were searched to identify relevant studies using GLP-1 as the keyword. Among the identified 26,539 studies, 30 clinical, and 71 preclinical studies were included. Data is presented by grouping rodent studies on palatable food intake, drugs of abuse, and studies on humans focusing on GLP-1 and reward systems. Results: GLP-1Rs are located in reward-related areas, and GLP-1, its agonists, and DPP-IV inhibitors are effective in decreasing palatable food intake, along with reducing cocaine, amphetamine, alcohol, and nicotine use in animals. GLP-1 modulates dopamine levels and glutamatergic neurotransmission, which results in observed behavioral changes. In humans, GLP-1 alters palatable food intake and improves activity deficits in the insula, hypothalamus, and orbitofrontal cortex (OFC). GLP-1 reduces food cravings partially by decreasing activity to the anticipation of food in the left insula of obese patients with diabetes and may inhibit overeating by increasing activity to the consumption of food in the right OFC of obese and left insula of obese with diabetes. Conclusion: Current preclinical studies support the view that GLP-1 can be a target for reward system related disorders. More translational research is needed to evaluate its efficacy on human reward system related disorders.
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DOI：
10.1523/jneurosci.3262-11.2011
发表时间：
2011-10-12
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Dossat AM;Lilly N;Kay K;Williams DL
通讯作者：
Williams DL
影响因子：
7.7
作者：
Daniele, Giuseppe;Iozzo, Patricia;Gastaldelli, Amalia
通讯作者：
Gastaldelli, Amalia
影响因子：
3.4
作者：
Bornebusch, Annika Billefeld;Fink-Jensen, Anders;Thomsen, Morgane
通讯作者：
Thomsen, Morgane
DOI：
10.1152/ajpregu.00179.2014
发表时间：
2014-08-15
影响因子：
2.8
作者：
Alhadeff, Amber L.;Grill, Harvey J.
通讯作者：
Grill, Harvey J.
影响因子：
4.8
作者：
Dailey, Megan J.;Stingl, Katherine C.;Moran, Timothy H.
通讯作者：
Moran, Timothy H.