The role of genetic variability in the SLC6A4, BDNF and GABRA6 genes in anxiety-related traits
The role of genetic variability in the SLC6A4, BDNF and GABRA6 genes in anxiety-related traits
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DOI：
10.1111/j.1600-0447.2011.01764.x
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发表时间：
2012-03-01
影响因子：
6.7
通讯作者：
Fananas, L.
中科院分区：
文献类型：
--
作者：
Arias, B.;Aguilera, M.;Fananas, L.
目的：本研究的目的是测试5-羟色胺转运体基因（SLC6A4）、脑源性神经营养因子基因（BDNF）和GABA（A）α（6）受体亚单位基因（GABRA6）与焦虑相关性状的个体关联，并探索西班牙健康样本中假定的基因-基因相互作用。937名被试完成了气质和性格问卷，以探讨伤害回避（HA）维度; 553人的子样本也填写了大五问卷，以探索神经质维度。结果：T1512C基因型T等位基因纯合子的HA评分略高于C等位基因携带者（F = 2.96，P = 0.019）;结论：GABRA6基因可能是影响HA变异的候选基因。SLC6A4和BDNF基因之间的显著基因-基因相互作用对HA的影响可以解释焦虑相关性状的部分遗传基础。
Objective: The aims of this study were to test the individual association of the serotonin transporter gene (SLC6A4), the brainderived neurotrophic factor gene (BDNF) and the GABA(A)alpha(6) receptor subunit gene (GABRA6) with anxiety-related traits and to explore putative gene-gene interactions in a Spanish healthy sample.Method: A sample of 937 individuals from the general population completed the Temperament and Character Inventory questionnaire to explore Harm Avoidance (HA) dimension; a subsample of 553 individuals also filled in the Big Five Questionnaire to explore the Neuroticism dimension. The whole sample was genotyped for the 5-HTTLPR polymorphism (SLC6A4 gene), the Val66Met polymorphism (BDNF gene) and the T1521C polymorphism (GABRA6 gene).Results: Homozygous individuals for the T allele of the T1512C polymorphism presented slightly higher scores for HA than C allele carriers (F = 2.96, P = 0.019). In addition, there was a significant gene-gene interaction on HA between the 5-HTTLPR and Val66Met polymorphisms (F = 3.4, P = 0.009).Conclusion: GABRA6 emerges as a candidate gene involved in the variability of HA. The effect of a significant gene-gene interaction between the SLC6A4 and BDNF genes on HA could explain part of the genetic basis underlying anxiety-related traits.