Enantioselective Synthesis of Cyclobutylboronates via a Copper-Catalyzed Desymmetrization Approach
Enantioselective Synthesis of Cyclobutylboronates via a Copper-Catalyzed Desymmetrization Approach
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DOI：
10.1002/anie.201601976
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发表时间：
2016-06-06
影响因子：
16.6
通讯作者：
Tortosa, Mariola
中科院分区：
文献类型：
--
作者：
Guisan-Ceinos, Manuel;Parra, Alejandro;Tortosa, Mariola
首次报道了手性铜配合物催化不对称合成环丁基硼酸酯。已经制备了具有一致高水平的非对映体和对映体控制的多种环丁烷。此外，该方法构成了对映选择性去对称化的meso-cyclobutenes制备手性环丁烷的第一个报告。
The first catalytic enantioselective synthesis of cyclobutylboronates, by using a chiral copper(I) complex, is reported. A broad variety of cyclobutanes have been prepared with consistently high levels of diastereo- and enantiocontrol. Moreover, this method constitutes the first report of an enantioselective desymmetrization of meso-cyclobutenes to prepare chiral cyclobutanes.