Pathophysiology of lower urinary tract symptoms in the aging male population.
Pathophysiology of lower urinary tract symptoms in the aging male population.
复制标题
老年男性人群下尿路症状的病理生理学。
DOI：
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
H. Lepor
中科院分区：
文献类型：
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作者：
H. Lepor
几乎所有的男性在80岁时都会出现组织学上的良性前列腺增生，但增生导致的前列腺肥大程度差异很大。历史上，人们通常认为男性下尿路症状（LUTS）的病理生理学是与前列腺肥大相关的膀胱出口梗阻的结果。前列腺增大、膀胱出口梗阻和LUTS均具有年龄依赖性的观察结果已被解释为表明这些现象存在因果关系，但证据不足。毫无疑问，有些男性的前列腺肥大会引起梗阻和症状。然而，根据现有数据，这一子集似乎非常小。由于许多泌尿系统和非泌尿系统疾病会导致LUTS以及膀胱和神经功能的年龄依赖性变化，因此老年男性人群不太可能存在单一的主导病因。如果是这种情况，那么LUTS的最佳管理将需要不同的，可能是联合治疗。
Nearly all men will develop histological benign prostatic hyperplasia by the age of 80, but the degree of prostatic enlargement resulting from the hyperplasia is highly variable. Historically, it has often been assumed that the pathophysiology of lower urinary tract symptoms (LUTS) in men is the result of bladder outlet obstruction associated with prostatic enlargement. The observation that prostatic enlargement, bladder outlet obstruction, and LUTS are all age-dependent has been interpreted to indicate that these phenomena were causally related, but there is insufficient evidence for this. Undoubtedly, some men's prostatic enlargement causes obstruction and symptoms. Based on the available data, however, this subset appears to be extremely small. Because of the many urological and nonurological conditions that cause LUTS and age-dependent changes in bladder and neurological function, it is unlikely that there exists a single dominant etiology for the aging male population. If this is the case, then the optimal management of LUTS will require different and possibly combination therapies.
DOI：
10.1001/jama.1993.03510070082041
发表时间：
1993-08
期刊：
JAMA
影响因子：
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作者：
J. E. Oesterling;S. Jacobsen;C. Chute;H. Guess;C. Girman;Laurei A. Panser;M. Lieber
通讯作者：
J. E. Oesterling;S. Jacobsen;C. Chute;H. Guess;C. Girman;Laurei A. Panser;M. Lieber