Neural Regulation of CNS Angiogenesis During Development.
Neural Regulation of CNS Angiogenesis During Development.
复制标题
DOI：
10.1007/s11515-014-1331-y
复制
发表时间：
2015-02
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
脊椎动物已经进化出一个强大的血管系统，涉及血管和靶组织之间的密切相互作用。几十年来，血管生物学主要集中在血管的研究上，这已经产生了大量关于血管细胞发育、功能和病理学的知识。我们认为，血管研究的血管-组织相互作用，特别是靶组织调节血管发育的黄金时间已经到来。中枢神经系统（CNS）需要一个高效的血管系统来运输氧气和营养物质以及废物处理。因此，神经血管的相互作用是一个很好的切入点，了解血管发育的靶组织调节。在这篇综述中，我们总结了在发育过程中从神经细胞向血管传递信息的信号通路，以及它们调节CNS血管生成的每个步骤的机制。我们还回顾了血脑屏障的建立和成熟的神经调节的重要机制，突出神经祖细胞和周细胞的不同功能。最后，我们评估了神经血管信号障碍对脑血管疾病发展的潜在贡献，并讨论了神经血管相互作用如何参与脑肿瘤血管生成。
Vertebrates have evolved a powerful vascular system that involves close interactions between blood vessels and target tissues. Vascular biology had been mostly focused on the study of blood vessels for decades, which has generated large bodies of knowledge on vascular cell development, function and pathology. We argue that the prime time has arrived for vascular research on vessel-tissue interactions, especially target tissue regulation of vessel development. The central nervous system (CNS) requires a highly efficient vascular system for oxygen and nutrient transport as well as waste disposal. Therefore, neurovascular interaction is an excellent entry point to understanding target tissue regulation of blood vessel development. In this review, we summarize signaling pathways that transmit information from neural cells to blood vessels during development and the mechanisms by which they regulate each step of CNS angiogenesis. We also review important mechanisms of neural regulation of blood-brain barrier establishment and maturation, highlighting different functions of neural progenitor cells and pericytes. Finally, we evaluate potential contribution of malfunctioning neurovascular signaling to the development of brain vascular diseases and discuss how neurovascular interactions could be involved in brain tumor angiogenesis.