CLONING OF IMMUNOGLOBULIN-SUPERFAMILY MEMBERS ASSOCIATED WITH HLA-C AND HLA-B RECOGNITION BY HUMAN NATURAL-KILLER-CELLS
CLONING OF IMMUNOGLOBULIN-SUPERFAMILY MEMBERS ASSOCIATED WITH HLA-C AND HLA-B RECOGNITION BY HUMAN NATURAL-KILLER-CELLS
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DOI：
10.1126/science.7716543
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发表时间：
1995-04-21
期刊：
影响因子：
56.9
通讯作者：
SAMARIDIS, J
中科院分区：
文献类型：
--
作者：
COLONNA, M;SAMARIDIS, J
Cytotoxicity by natural killer (NK) cells is inhibited by major histocompatibility complex (MHC) class I molecules on target cells. This inhibition may be mediated by NK receptors with different MHC specificities. A family of four NK-specific complementary DNAs (cDNAs), designated NKATs (NK-associated transcripts), was identified that encoded related transmembrane proteins, characterized by an extracellular region with two or three immunoglobulin-superfamily domains and by a cytoplasmic domain with an unusual antigen receptor activation motif (ARAM). The distribution of these cDNAs was clonotypic and correlated with NK cell inhibition by particular class I alleles. Thus, NKAT cDNAs may encode receptors for class I molecules on NK cells.
