fMRI evaluation of hemispheric language dominance using various methods of laterality index calculation
fMRI evaluation of hemispheric language dominance using various methods of laterality index calculation
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DOI：
10.1007/s00221-006-0794-y
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发表时间：
2007-05-01
影响因子：
2
通讯作者：
Rektor, Ivan
中科院分区：
文献类型：
--
作者：
Chlebus, Pavel;Mikl, Michal;Rektor, Ivan
几个功能性磁共振成像研究评估偏侧的语言功能的患者谁接受了Wada测试的报告。在不同研究中，偏侧指数（LI）的计算存在广泛差异，最佳计算方法仍不清楚。我们尝试在相同的主题以不同的方式计算LI，以找到LI计算方法与Wada测试的相关性最高。15名患有难治性颞叶癫痫（TLE）的患者（10名女性，5名男性）（12名左侧，3名右侧）被纳入研究。患者接受了标准化的双侧颈动脉内短效巴比妥酸盐试验。语言测试包括自发言语、口语理解、阅读、物体和图片命名以及重复。为了增加Wada和LI之间相关性的可能性，所有任务都被单独评分。一个无声的音素言语流畅性任务（VFT）被用作功能测量的语言范式。感兴趣区域（ROI），与语言功能（布罗卡区，外侧前额叶皮层等）有已知的关联，被定义。首先，使用先前报告的方法（简单阈上计数）从ROI计算LI。接下来，我们使用了几种新的LI计算方法（体素的t加权，与统计阈值的选择无关的方法等）。与Wada的最显著相关性在从Broca区评估的LI中得到证实（高达R = 0.94，P = 1 x 10（-7））。然而，与以前报道的方法相比，本研究中使用的新LI计算方法没有产生统计学显著性益处。
Several functional MR imaging studies evaluating the lateralisation of linguistic functions in patients who underwent Wada testing have been reported. There is extensive variance in the Laterality index (LI) calculation across the studies, and the optimal calculation method remains unclear. We attempted to calculate the LI in different ways in the same subjects, in order to find the LI calculation method with the highest correlation to the Wada test. Fifteen patients (10 females, 5 males) suffering from medically intractable temporal lobe epilepsy (TLE) (12 left, 3 right) were admitted for the study. The patients underwent a standardized bilateral intracarotid short-acting barbiturate test. Language testing included spontaneous speech, oral comprehension, reading, object and picture naming, and repetition. All the tasks were scored separately in order to increase the possibility of correlation between Wada and LI. A silent phonemic verbal fluency task (VFT) was used as a language paradigm for functional measurement. Regions of interest (ROIs), with a known association with language function (Broca's area, the lateral prefrontal cortex, etc.), were defined. First, the LIs were calculated from the ROIs using a previously reported method (simple suprathreshold count). Next, we used several new methods of LI calculation (t-weighting of voxels, methods independent of the choice of the statistical threshold, etc.) The most significant correlation with Wada was proven in the LIs that were evaluated from Broca's area (up to R = 0.94, P = 1 x 10(-7)). However, the new LI calculation methods used in the present study did not produce a statistically significant benefit in comparison to previously reported methods.