Phytoradiotherapy: An Integrative Approach to Cancer Treatment by Combining Radiotherapy With Phytomedicines.
Phytoradiotherapy: An Integrative Approach to Cancer Treatment by Combining Radiotherapy With Phytomedicines.
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DOI：
10.3389/fonc.2020.624663
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发表时间：
2020
影响因子：
4.7
通讯作者：
Avery S
中科院分区：
文献类型：
--
作者：
Alfonzetti T;Yasmin-Karim S;Ngwa W;Avery S
放射治疗（RT）是一种有效的癌症治疗方法，但与任何其他癌症治疗方法一样，也存在固有的局限性。虽然技术进步和对其生物学效应的日益了解显着改善了其结果，但RT的使用仍然限于某些患者人群和正常组织毒性。放射治疗患者的有害副作用可以抵消其治疗益处，限制其在某些情况下的使用。植物性药物提供了一种增加放射治疗的方法，同时也保护患者免受其毒副作用的影响。植物药物如大麻素（CBD）和苦瓜提取物已证明具有治疗特性，包括激活癌细胞凋亡死亡，减少肿瘤进展，并通常降低几种癌症类型的发病率。此外，草药已被证明是强大的抗氧化剂，具有降低RT毒性的能力，而没有合成药物中发现的不良副作用。此外，许多植物药物已被证明可以减轻肿瘤微环境中的缺氧条件，产生更放射敏感的疾病并预防肿瘤发生。本文的目的是研究的优点和缺点，采用植物药在RT。结果从研究中已经测试了放射治疗与补充草药治疗相结合的效果进行了讨论沿着的观点，在需要额外的研究，以推进“植物放射疗法”。总的来说，实验证据表明，植物药具有显著的提高RT的潜力，需要跨学科合作，以建立具有临床转化证据基础的最佳剂量组合。
Radiotherapy (RT) is an effective method of cancer treatment, but like any other method of cancer treatment, there are inherent limitations. While technological advances and a growing understanding of its biological effects have improved its results dramatically, the use of RT is still limited to certain patient populations and by normal tissue toxicities. The harmful side effects of treating patients with radiation can offset its therapy benefits, limiting its use in certain cases. Phyto, or plant-based, medicines offer a way to add to radiation treatment, while also protecting patients from its toxic side effects. Phytomedicines such as cannabinoids (CBD) and bitter melon extract have demonstrated therapeutic properties, including the ability to activate apoptotic death in cancer cells, diminish tumor progression, and generally decrease the incidence of several cancer types. In addition, herbal drugs have been shown to be powerful antioxidants with the ability to decrease toxicity of RT without the adverse side effects found in synthetic drugs. Furthermore, a number of phytomedicines have been shown to mitigate hypoxic conditions within the tumor microenvironment, creating a more radiosensitive disease and preventing tumorigenesis. The purpose of this article is to examine the merits and demerits of employing phytomedicines during RT. Results from studies that have tested the effects of combining radiotherapy with supplemental herbal treatment are discussed along with perspectives on where additional research is needed to advance “Phytoradiotherapy”. Overall, experimental evidence points to the fact that phytomedicines have significant potential to enhance RT, with need for cross-disciplinary collaborations to establish optimal dosing combinations with evidence-base for clinical translation.
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