HIGH-RESOLUTION 2-DIMENSIONAL ELECTROPHORESIS OF HUMAN-PLASMA PROTEINS
HIGH-RESOLUTION 2-DIMENSIONAL ELECTROPHORESIS OF HUMAN-PLASMA PROTEINS
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DOI：
10.1073/pnas.74.12.5421
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发表时间：
1977-01-01
影响因子：
11.1
通讯作者：
ANDERSON, NG
中科院分区：
文献类型：
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作者：
ANDERSON, L;ANDERSON, NG
O‘’Farrell双向电泳法被应用于人类血浆蛋白的分析，在产生的模式中鉴定了30个多肽。涉及电荷(等电点)或大小(在十二烷基硫酸钠存在下的分子量)变化的遗传变异应该在至少20个蛋白质中一次常规检测到，这有助于研究人类突变率。
The 2-dimensional electrophoretic technique of O''Farrell was adapted to the analysis of human plasma proteins, and 30 polypeptides were identified in the pattern produced. Genetic variants involving charge (isoelectric point) or size (MW in the presence of sodium dodecyl sulfate) changes should be routinely detectable in at least 20 proteins at once, facilitating studies of human mutation rates.