Behavioural cue reactivity to alcohol-related and non-alcohol-related stimuli among individuals with alcohol use disorder: An fMRI study with a visual task
Behavioural cue reactivity to alcohol-related and non-alcohol-related stimuli among individuals with alcohol use disorder: An fMRI study with a visual task
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DOI：
10.1371/journal.pone.0229187
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发表时间：
2020-07-17
期刊：
影响因子：
3.7
通讯作者：
Ueno, Takefumi
中科院分区：
文献类型：
--
作者：
Fukushima, Shou;Kuga, Hironori;Ueno, Takefumi
酒精使用障碍（AUD）患者难以控制他们对酒精的渴望，因此表现出增加的使用和早期复发。尽管患者对与酒精有关的图像的反应往往比非酒精相关的图像更强烈，但很少有研究人员研究了调节渴望的因素。在这里，我们检查了AUD患者和健康对照组（hc）对行为线索的全脑血氧水平依赖（BOLD）反应。参与者包括24例AUD患者和15例hcc患者。我们提供了四种与饮料相关的视觉线索（果汁、喝果汁、清酒和喝清酒），并对比了AUD参与者和HC参与者的线索反应性。多重比较显示，AUD组对饮用果汁图像的左楔形前叶（p = 0.036）和左扣带后皮层（PCC）的BOLD反应低于HC组（p = 0.044），对饮用清酒图像的左扣带后皮层（PCC）的BOLD反应高于HC组（p = 0.044）。此外，与hc患者相比，AUD患者在15 - 18秒（p = 0.004, df = 37）和18 - 21秒（p = 0.002, df = 37）期间，左侧楔形前叶饮用果汁的线索反应性BOLD反应降低。我们的研究结果表明，hc和AUD患者对酒精饮料图像的反应不同，但对与饮酒行为相关的图像的反应不同。因此，这些病人似乎有不同的大脑活动模式。这些信息可以帮助临床医生开发AUD患者的治疗方法。
Patients with alcohol use disorder (AUD) have difficulty controlling their alcohol cravings and thus exhibit increased use and early relapse. Although patients tend to respond more strongly to alcohol-related images than to non-alcohol-related images, few researchers have examined the factors that modulate cravings. Here, we examined whole-brain blood oxygen level-dependent (BOLD) responses to behavioural cues in individuals with AUD and in healthy controls (HCs). The participants included 24 patients with AUD and 15 HCs. We presented visual cues consisting of four beverage-related images (juice, drinking juice, sake, and drinking sake), and the cue reactivity of AUD participants was contrasted with that of HC participants. Multiple comparisons revealed that the AUD group had lower BOLD responses than the HC group in the left precuneus (p = 0.036) and the left posterior cingulate cortex (PCC) (p = 0.044) to images of drinking juice and higher BOLD responses than the HC group in the left PCC (p = 0.044) to images of drinking sake. Furthermore, compared to the HCs, the AUD patients had decreased BOLD responses associated with cue reactivity to drinking juice in the left precuneus during the periods from 15 to 18 s (p = 0.004, df = 37) and 18 to 21 s (p = 0.002, df = 37). Our findings suggest that HCs and AUD patients differ in their responses not to images of alcoholic beverages but to images related to alcohol-drinking behaviour. Thus, these patients appear to have different patterns of brain activity. This information may aid clinicians in developing treatments for patients with AUD.