Hmga1/Hmga2 double knock-out mice display a "superpygmy" phenotype.
Hmga1/Hmga2 double knock-out mice display a "superpygmy" phenotype.
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DOI：
10.1242/bio.20146759
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发表时间：
2014-04-11
期刊：
影响因子：
2.4
通讯作者：
Fusco A
中科院分区：
文献类型：
--
作者：
Federico A;Forzati F;Esposito F;Arra C;Palma G;Barbieri A;Palmieri D;Fedele M;Pierantoni GM;De Martino I;Fusco A
HMGA 1和HMGA 2基因编码属于高迁移率族A家族的蛋白质。一些基因受到这两种蛋白质的负调控或正调控，但许多基因仅受到其中一种蛋白质的特异性调控。事实上，Hmga 1和Hmga 2基因的敲除导致不同的表型：前一种情况下的心脏肥大和2型糖尿病，后一种情况下的身体尺寸和脂肪组织量大幅减少。因此，为了更好地阐明Hmga基因的功能，我们将Hmga 1缺失小鼠与Hmga 2缺失小鼠杂交。Hmga 1 −/−/Hmga 2 −/−小鼠表现出活力降低和非常小的体型（比野生型小鼠小75%）;它们甚至比侏儒Hmga 2缺失小鼠还要小。E2 F1活性的急剧降低，以及因此参与细胞周期调节的E2 F依赖性基因的表达的急剧降低，可能解释了Hmga 1 −/−/Hmga 2 −/−小鼠的一些表型特征。
The HMGA1 and HMGA2 genes code for proteins belonging to the High Mobility Group A family. Several genes are negatively or positively regulated by both these proteins, but a number of genes are specifically regulated by only one of them. Indeed, knock-out of the Hmga1 and Hmga2 genes leads to different phenotypes: cardiac hypertrophy and type 2 diabetes in the former case, and a large reduction in body size and amount of fat tissue in the latter case. Therefore, to better elucidate the functions of the Hmga genes, we crossed Hmga1-null mice with mice null for Hmga2. The Hmga1−/−/Hmga2−/− mice showed reduced vitality and a very small size (75% smaller than the wild-type mice); they were even smaller than pygmy Hmga2-null mice. The drastic reduction in E2F1 activity, and consequently in the expression of the E2F-dependent genes involved in cell cycle regulation, likely accounts for some phenotypic features of the Hmga1−/−/Hmga2−/− mice.
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影响因子：
5.3
作者：
JOHNSON, KR;LEHN, DA;REEVES, R
通讯作者：
REEVES, R
影响因子：
82.9
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通讯作者：
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50.3
作者：
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影响因子：
11.2
作者：
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通讯作者：
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影响因子：
11.2
作者：
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通讯作者：
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