Heterogeneously vancomycin-intermediate Staphylococcus aureus (hVISA) emerged before the clinical introduction of vancomycin in Japan: a retrospective study
Heterogeneously vancomycin-intermediate Staphylococcus aureus (hVISA) emerged before the clinical introduction of vancomycin in Japan: a retrospective study
复制标题
DOI：
10.1007/s10156-011-0330-2
复制
发表时间：
2012
影响因子：
2.2
通讯作者：
Junki Yamakawa;M. Aminaka;K. Okuzumi;Hiroyoshi Kobayashi;Y. Katayama;Shigemi Kondo;A. Nakamura;T. Oguri;S. Hori;L. Cui;Teruyo Ito;Jingxun Jin;H. Kurosawa;K. Kaneko;K. Hiramatsu
中科院分区：
文献类型：
--
作者：
Junki Yamakawa;M. Aminaka;K. Okuzumi;Hiroyoshi Kobayashi;Y. Katayama;Shigemi Kondo;A. Nakamura;T. Oguri;S. Hori;L. Cui;Teruyo Ito;Jingxun Jin;H. Kurosawa;K. Kaneko;K. Hiramatsu
Vancomycin-intermediateStaphylococcus aureus(VISA) and its precursor, heterogeneous VISA (hVISA), are increasingly the cause of vancomycin treatment failure. Prolonged glycopeptide treatment causes the emergence of these pathogens. However, we recently reported that hVISA can be generated by methicillin-resistantS. aureus(MRSA) exposure to imipenem (Katayama et al., Antimicrob Agents Chemother. 53:3190–6). We report here a retrospective prevalence study of VISA and hVISA on 750 MRSA clinical strains isolated from 31 Japanese national university hospitals in 1990, the year before the introduction of injectable vancomycin into clinical use in Japan in 1991. No VISA strain was identified, but population analysis identified 38 hVISA strains (5.1%) from 19 hospitals. We also determined the nucleotide sequences ofvraSR,walRK,clpP, andrpoBgenes whose mutations are known to be associated with vancomycin resistance. When compared with vancomycin-susceptible MRSA strain N315, six of the 38 hVISA strains possessed nonsynonymous mutations invraSR, seven inwalRK, and two inrpoBgenes, Thirteen of 38 (34.2%) hVISA strains possessed at least one of these mutations. Results were consistent with our hypothesis that hVISA was present in Japanese hospitals before the clinical introduction of vancomycin.
