Acute childhood leukaemia and residence next to petrol stations and automotive repair garages: the ESCALE study (SFCE)
Acute childhood leukaemia and residence next to petrol stations and automotive repair garages: the ESCALE study (SFCE)
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DOI：
10.1136/oem.2008.042432
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发表时间：
2009-09-01
影响因子：
4.9
通讯作者：
Clavel, J.
中科院分区：
文献类型：
--
作者：
Brosselin, P.;Rudant, J.;Clavel, J.
背景：2003-2004年在法国进行的一项基于国家登记的病例对照研究分析了儿童急性白血病与居住在加油站和汽车修理厂附近之间的关系。方法：人口控制与病例在年龄和性别上频繁匹配。数据是通过标准化的电话采访母亲收集的。后者被要求报告从怀孕到确诊(病例)或面谈(对照)，他们的家离加油站、汽车修理厂和其他企业很近。根据年龄、性别、家庭中15岁以下儿童的数量、城市化程度和住房类型进行调整后的非条件回归模型估计优势比。结果：纳入765例急性白血病患者和1681名对照。急性白血病与居住在加油站或汽车修理厂附近(OR 1.6，95%CI 1.2~2.2)和加油站附近(OR 1.9，95%CI 1.2~3.0)显著相关。OR值无随接触时间延长而增加的趋势。结论：研究结果支持我们先前的研究结果，并提示居住在加油站旁边的人可能与儿童急性白血病有关。结果还表明，低水平的苯暴露在儿童急性白血病中的作用值得进一步评估。
Background: The association between acute childhood leukaemia and residing next to petrol stations and automotive repair garages was analysed in a national registry-based case-control study carried out in France in 2003-2004.Methods: Population controls were frequency matched with cases on age and gender. Data were collected by standardised telephone interview with the mothers. The latter were asked to report the proximity of their homes to petrol stations, automotive repair garages and other businesses from the conception of the index child to the diagnosis (for cases) or interview (for controls). Odds ratios were estimated using unconditional regression models adjusted for age, gender, number of children under 15 years of age in the household, degree of urbanisation and type of housing.Results: 765 cases of acute leukaemia and 1681 controls were included. Acute leukaemia was significantly associated with residence next to petrol stations or automotive repair garages (OR 1.6, 95% Cl 1.2 to 2.2) and next to a petrol station (OR 1.9, 95% Cl 1.2 to 3.0). The OR showed no tendency to increase with duration of exposure. The results were not modified by adjustment for potential confounding factors including urban/rural status and type of housing.Conclusions: The results support the findings of our previous study and suggest that living next to a petrol station may be associated with acute childhood leukaemia. The results also suggest that the role of low-level exposure to benzene in acute childhood leukaemia deserves further evaluation.