Urothelial Carcinoma: Divergent Differentiation and Morphologic Subtypes.
Urothelial Carcinoma: Divergent Differentiation and Morphologic Subtypes.
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DOI：
10.1016/j.path.2022.07.003
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发表时间：
2022-12
影响因子：
--
通讯作者：
Al-Ahmadie, Hikmat
中科院分区：
文献类型：
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作者：
Gandhi, Jatin;Chen, Jie-Fu;Al-Ahmadie, Hikmat
尿路上皮癌（UC）是已知的，包括广泛的形态学特征和分子改变。大约15%-25%的浸润性UC表现出组织形态学特征，其形式为沿其他上皮谱系的“趋异分化”沿着，或尿路上皮分化的不同“亚型/变体”。建议尽可能报告分化差异和/或亚型/变异的百分比。分子生物学的最新进展使我们对这些形态学变异的分子基础有了更好的理解。在这篇综述中，我们强调了不同分化的组织学特征和亚型公认的最新版本的WHO分类，其分子和临床特征的更新。
Urothelial carcinoma (UC) is known to encompass a wide spectrum of morphologic features and molecular alterations. Approximately 15% to 25% of invasive UC exhibits histomorphologic features in the form of “divergent differentiation” along other epithelial lineages, or different “subtypes/variants” of urothelial differentiation. It is recommended that the percentage of divergent differentiation and or subtype(s)/ variant(s) be reported when possible. Recent advances in molecular biology have led to better understanding of molecular underpinning of these morphologic variations. In this review, we highlight histologic characteristics of the divergent differentiation and subtypes recognized by the latest version of WHO classification, with updates on their molecular and clinical features.