Randomized trial of dietary fiber and Lactobacillus casei administration for prevention of colorectal tumors
Randomized trial of dietary fiber and Lactobacillus casei administration for prevention of colorectal tumors
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DOI：
10.1002/ijc.21115
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发表时间：
2005-09-20
影响因子：
6.4
通讯作者：
Kakizoe, T
中科院分区：
文献类型：
--
作者：
Ishikawa, H;Akedo, I;Kakizoe, T
膳食纤维预防结直肠癌的流行病学证据是模棱两可的。没有关于干酪乳杆菌给药的大规模临床研究的报道。我们研究了膳食纤维和干酪乳杆菌是否能预防结直肠肿瘤的发生。研究对象为398名已切除至少2个结直肠肿瘤的无肿瘤男性和女性。受试者被随机分为4组，分别给予麦麸、干酪乳杆菌、两者都给予或不给予。主要终点是2年和4年后结肠镜检查诊断的新结直肠肿瘤的存在或不存在。在380名完成研究的受试者中，分别有95人、96人、96人和93人被分配到麦麸组、干酪乳杆菌组和无治疗组。与对照组相比，麦麸组和干酪乳杆菌组肿瘤发生的多因素调整后的or值分别为1.31 （95% CI 0.87-1.98）和0.76（0.50-1.15）。4年后，麦麸组的大肿瘤数量明显增加。中度或以上非典型性肿瘤的发生率在给予干酪乳杆菌组明显降低。使用麦麸或干酪乳杆菌对新结直肠肿瘤的发展没有显著差异。然而，我们的研究结果表明，干酪乳杆菌可以预防结直肠癌的非典型性。(c) 2005 Wiley-Liss, Inc。
The epidemiologic evidence that dietary fiber protects against colorectal cancer is equivocal. No large-scale clinical study of the administration of Lactobacillus casei has been reported. We examined whether dietary fiber and L. casei prevented the occurrence of colorectal tumors. Subjects were 398 men and women presently free from tumor who had had at least 2 colorectal tumors removed. Subjects were randomly assigned to 4 groups administered wheat bran, L. casei, both or neither. The primary end point was the presence or absence of new colorectal tumor(s) diagnosed by colonoscopy after 2 and 4 years. Among 380 subjects who completed the study, 95, 96, 96 and 93 were assigned to the wheat bran, L. casei, both and no treatment groups, respectively. Multivariate adjusted ORs for occurrence of tumors were 1.31 (95% CI 0.87-1.98) in the wheat bran group and 0.76 (0.50-1.15) in the L. casei group compared to the control group. There was a significantly higher number of large tumors after 4 years in the wheat bran group. The occurrence rate of tumors with a grade of moderate atypia or higher was significantly lower in the group administered L. casei. No significant difference in the development of new colorectal tumors was observed with administration of either wheat bran or L. casei. However, our results suggest that L. casei prevented atypia of colorectal tumors. (c) 2005 Wiley-Liss, Inc.