Saliva Liquid Biopsy for Point-of-Care Applications.
Saliva Liquid Biopsy for Point-of-Care Applications.
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DOI：
10.3389/fpubh.2017.00077
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发表时间：
2017
影响因子：
5.2
通讯作者：
Tu M
中科院分区：
文献类型：
--
作者：
Aro K;Wei F;Wong DT;Tu M
唾液是一种非侵入性生物流体，易于收集、运输和储存。由于唾液的可及性以及与全身性疾病的联系，唾液是推动即时医疗进步的最佳候选者之一，个人可以通过使用智能手机等便携式便利工具轻松监测自己的健康状况。唾液的用途有很多种：已经有研究利用唾液来测量应激激素、酶水平、发育疾病生物标志物，甚至癌症突变。如果经过验证的生物标志物与高质量的检测工具相结合，唾液将开辟高质量医疗保健的新领域，使医生和患者能够共同努力进行实时健康监测和高影响力的个性化预防医学。唾液最令人兴奋的新兴领域之一是液体活检，这是一种评估患者癌症的存在和特征的非侵入性方法。本文将回顾当前生物标志物的基础知识，回顾它们与不同疾病和病症的关系，并探索液体活检的即时应用。
Saliva is a non-invasive biofluid, which is easy to collect, transport, and store. Because of its accessibility and connection to systemic diseases, saliva is one of the best candidates for the advancement of point-of-care medicine, where individuals are able to easily monitor their health status by using portable convenient tools such as smartphones. There are a variety of scenarios with which saliva can be used: studies have been conducted on using saliva to measure stress hormones, enzyme levels, developmental disease biomarkers, and even cancer mutations. If validated biomarkers were combined with high-quality detection tools, saliva would open up a new frontier in high-quality healthcare, allowing physicians and patients to work together for real-time health monitoring and high-impact personalized preventative medicine. One of the most exciting emerging frontiers of saliva is liquid biopsy, which is a non-invasive means to assess the presence and characteristics of cancer in a patient. This article will review current basic knowledge of biomarkers, review their relation to different diseases and conditions, and explore liquid biopsy for point-of-care applications.